摘要
研究对象包括正常对照、NPC患者及血清EB病毒相关抗体IgA/EA阳性和IgA/EA阴性而IgA/VCA阳性等NPC高危人群。NPC患者及NPC高危人群淋巴细胞BP的SCE诱发率显著高于对照。在有G6PD抑制剂DHEA存在时,这种差异进一步增大。而且,几个组间BP+DHEA的SCE诱发率均值及个体分布呈现明显的不同,这种差异与几个人群间NPC风险程度的差别相当吻合。可以认为,在区分NPC风险程度不同的人群方面,BP+DHEA SCE诱发试验可能是一个比较有效的方法,但能否作为一个检出NPC易感个体的实用指标,还有待前瞻观察的结果。
Subjects for study included four groups: 1) NPC patients, 2) serum EBV IgA/EA and IgA/VCA antibody positive individuals, 3) IgA/VCA antibody positive but IgA/EA negative individuals and 4) IgA/VCA antibody negative individuals (normal controls). BP-indu-ced SCE rates (induced SCE rate= induced SCE frequency X 100/spontaneous SCE frequency) were 124.2±21, 120.2±23, 113.3±18 and 101.2±9.3 in NPC, EA(+), VCA(+) and VCA (-) groups respectively. This rate was significantly higher in NPC, EA(+) and VCA (+) persons than in VCA(-) ones, but there was no significant difference among NPC, EA(+) and VCA(+) groups. BP+DHEA-induced SCE rates were 161.4±25, 147.4±32, 122.5±25 and 107.0±7.4 in NPC, EA(+), VCA(+) and VCA(-) groups respectively. It was significantly high'er in NPC, EA(+) and VCA(+) persons than in VCA(-) ones. Furthermore, there was a significant difference among NPC, EA(+) and VCA(+) groups. The individual distribution of BP+DHEA-induced SCE rate also showed a significant difference statistically. The differences of BP+DHEA induced SCE rates and of their individual distributions among these four groups were consistent with the difference in predisposition to NPC in these populations, judged by epidemiological data. It was resonable to suggest that BP+DHEA -induced SCE test might have some correlation to the NPC risk. Whether it can be used as a marker for screening the NPC high risk individuals remains to be proved in the prospective observation.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1990年第4期276-279,共4页
Chinese Journal of Cancer
