摘要
目的观察舒血宁注射液治疗冠状动脉粥样硬化性心脏病心绞痛的临床疗效与安全性。方法将100例冠心病心绞痛患者随机分为2组。治疗组50例,采用舒血宁注射液5 ml加入5%葡萄糖注射液250 ml(有糖尿病者改用0.9%氯化钠注射液250 ml)稀释后静脉滴注,每日1次;对照组50例,口服单硝酸异山梨酯缓释片,每次40 mg,每日1次。观察2组心绞痛疗效、心电图变化、动态心电图缺血性ST-T改变时间、血液流变学及血脂变化情况。结果治疗组、对照组心绞痛总有效率分别为96%、60%,2组比较有显著性差异(P<0.05);治疗组、对照组心电图总有效率分别为76%、50%,2组比较有显著性差异(P<0.05)。治疗后2组动态心电图缺血性ST-T改变时间比较有显著性差异(P<0.05)。2组治疗后血液流变学及血脂指标变化均有显著性差异。结论舒血宁注射液治疗冠状动脉粥样硬化性心脏病心绞痛比单硝酸异山梨酯缓释片效果好,且安全性较好,无明显副作用。
Objective To obeerve the therapeufie effect of Shuxuening injection on angina pectoris. Methods 100 patients with angina pectofis were randomly divided into two groups. 50 patients in treatment group were venously treated with Shuxuening Injection 5mililiter resolving in the 250 mililiter 5% glucose injection, once a day （patients with diabetes were given 0.9% sodium chloride injection instead）. 50 partients in control group were treated with isosorbide mononitrate 40 mg, once a day. The symptoms, alter of ECG （ ischemic ST-T changes）, holter ECG, blood viscosity and blood fat were investigated. Results The total effective rate was 96% and 60% in the treatment group and the control group respectively （ P 〈 0.05）. The ST-T segment improve rate was 76% and 50% in the treatment group and the control group respectively （ P 〈0.05）. The time of isehemic ST-T segment in the Holter ECG decreased from （130.45 ± 18,61）rain to（32.33 ± 5.32）min. Compared with the control group, there was a significant difference （ P 〈 0.05）. There was no significant difference on routine laboratory test and the heart, liver and kidney function before and after treatment in both groups. Conclusion Shuxuening Injection has definite clinical effect on angina pectofis and there is no side effects observed
出处
《河北中医》
2006年第1期61-63,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
舒血宁
冠状动脉疾病
心绞痛
中医药疗法
Shuxuening injection
Coronary artery disease
Angina pectoris
TCM
