摘要
目的对海洋真菌Aspergillussp.发酵液的乙酸乙酯萃取物进行化学成分的研究。方法采用硅胶柱色谱、凝胶柱色谱、高效液相色谱等手段,利用理化和波谱分析方法,对海洋真菌Aspergillussp.发酵液的乙酸乙酯萃取物的化学成分进行分离鉴定。结果与结论从该真菌发酵液的乙酸乙酯萃取物中分离得到8个二肽类化合物,经光谱数据分析,鉴定它们的结构分别为3-苯甲基-6-异丙基哌嗪-2,5-二酮(1)、3-苯甲基-6-异丁基哌嗪-2,5-二酮(2)、3-苯甲基-6-另丁基哌嗪-2,5-二酮(3)、3,6-二苯甲基哌嗪-2,5-二酮(4)、3-异丁基-6-异丙基哌嗪-2,5-二酮(5)、3-另丁基-6-异丁基哌嗪-2,5-二酮(6)、3-另丁基-6-异丙基哌嗪-2,5-二酮(7)、3-异丁基-吡咯并哌嗪-1,4-二酮(8)。这些化合物均是首次从该真菌代谢物中分离得到。
Aim To study the chemical constituents from the broth of marine fungus Aspergillus sp. Methods The compounds were separated by column chromatography and their structures were elucidated based on chemical and spectral analysis. Result and conclusion Eight compounds were isolated from the ethyl acetate extracts of the broth of Aspergillus sp. Their structures were determined as 3-benzyl-6-isopropylpiperazine- 2, 5-dione（1 ）, 3-benzyl-6-isobutylpiperazine-2, 5-dione（2）, 3- benzyl-6- sec-butylpiperazine-2, 5-dione（3）, 3, 6-dibenzylpiperazine-2, 5-dione （ 4 ）, 3-isobutyl-6-isopropylpiperazine-2, 5-dione （ 5 ）, 3-sec-butyl-6- isobutylpiperazine-2, 5-dione （ 6 ）, 3-sec-butyl-6-isopropylpiperazine-2, 5-dione （ 7 ）, 3-isobutylhexahydro- pyrrolo[ 1,2-a]pyrazine-1, 4-dione（8）. All of the compounds are obtained from this marine fungus for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2006年第1期37-39,共3页
Chinese Journal of Medicinal Chemistry
基金
国家高技术研究发展计划项目(2001AA624020)
