摘要
本实验对双歧杆菌ＤＭ８５０４菌苗抗小鼠肝癌及对其免疫功能的影响进行了研究。通过测定植瘤后小鼠生存率、平均存活期及抑瘤率和几项免疫学指标来评价。实验结果表明，该菌苗可明显降低植瘤小鼠死亡率并延长其平均存活期，以预防及治疗两种途径给予该菌苗可使ＮＫ细胞活性增高、巨噬细胞消化能力增强，并可提高脾细胞对ＣｏｎＡ的增殖反应性及血清中ＴＮＦ－α的活性。本文提示，ＤＭ８５０４菌苗具有一定的抗肿瘤作用及免疫调节能力。
The effect of Bifidobacterium adolescentis DM8504 strain on the growth of the mouse with transplantable hepatocarcinoma and its immunological system was studied.The effect was evaluated according to following indicator:the mean transplantable weight(MTW);death ration(DR);survival time(ST)and immunological test.The results showed that this DM8504 Vaccine injected by subcutaneous way could inhibit the growth of the transplantable mouse hepatocarcinoma and also prolonging the ST and the living ratio,whether it was injected before or after the inoculation of the tumor cells,By this injecting way,we found that DM8504 Vaccine could enhance the macrophagocytic phagocytosis,the activity of neutral killer cell,the reproducing response of the spleen lymophocyte to ConA and increase the content of TNF-αin serum statistically.It is suggested that DM8504Vaccine possesses a certain promotion on antitumor effect and the immunological modifing effect.The results were efficient.
出处
《中国微生态学杂志》
CAS
CSCD
1996年第2期5-10,共6页
Chinese Journal of Microecology
关键词
双歧杆菌
微生态制剂
肝癌
免疫功能
Bifidobacterium Macrophage Natural killer cell Reproducing response to ConA TNF-α Antitumor effect
