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黑色素瘤抗独特型抗体疫苗研究进展 被引量：1

Research Progress in Anti-Idiotypic Antibody Vaccine against Melanoma
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摘要 抗独特型抗体免疫治疗是肿瘤治疗的新途径。黑色素瘤抗独特型抗体疫苗能模拟肿瘤相关抗原,激发机体的抗肿瘤免疫应答,已在许多动物实验和临床试验中得到证实。现综述抗独特型抗体疫苗在黑色素瘤治疗方面的研究进展。 Immunization with anti-idiotypic antibodies represents a novcl approach to active immunotherapy for tumors. It has been demonstrated that anti-idiotypic antibody vaccines against melanoma can mimic tumor-associated antigens and activate anti-tumor immune responses in many animal models and clinical trials. The research progress in anti-idiotypic antibody vaccines against melanoma is reviewed.
作者 刘洁 马洁
机构地区 中国协和医科大学中国医学科学院肿瘤研究所
出处 《现代诊断与治疗》 CAS 2006年第1期30-32,共3页 Modern Diagnosis and Treatment
关键词 黑色素瘤 抗独特型抗体 免疫治疗 Melanoma Anti-idiotypic antibody Immunotherapy
分类号 R392.11 [医药卫生—免疫学]
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参考文献12

  • 1Bhattacharya-Chatterjee M, Chatterjee SK, goon KA. The anti-idiotype vaccines for immunotherapy [J]. Curr Opin Mol Ther, 2001,3 ( 1 ) : 63-69.
  • 2Wang X,Ko EC ,Peng L,et al. Human high molectdar weight melanomaassociated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23:enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2 [ J]. Cancer Res,2005,65( 15 ) :6976-6983.
  • 3Fernandez LE, Alonso DF, Gomez DE, et al. Ganglioside-based vaccines and anti-idiotypic antibodies for active immunotherapy against cancer[J]. Expert Rev Vaccines,2003,2(6):817-823.
  • 4Chapman PB. Vaccinating against GD3 ganglioside using BEC2 anti-idiotypic monoclonal antibody [ J ]. Curr Opin Invest Drugs, 2003,4 ( 6 ) :710-715.
  • 5Zeytin HE, Tripathi PK, Bhattacharya-Chatterjee M, et al. Construction and characterization of DNA vaccines encoding the single-chain variable fragment of the anti-idiotypie antibody 1A7 mimicking the tumor-associated antigen disialoganglloside GD2 [ J ]. Cancer Gene Ther, 2000,7(11):1426-1436.
  • 6Basak S,Birebent B ,Purev E,et al. Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside[ J ]. Cancer Immunol Immunother,2003,52( 3 ) : 145-154.
  • 7Lutzky J, Gonzalez-Angulo AM, Orzano JA. Antibody-based vaccines for the treatment of melanoma[ J]. Semin Oncol,2002,29( 5 ) :462-470.
  • 8Mittelman A, Chen GZ, Wang GY, et al. Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypie monoclonal antibody MK2-23 :modulatlon of the immunogenicity in patients with malignant melanoma[J]. Clin Cancer Res,1995,1(7) :705-713.
  • 9Chapman PB, Wu D, Ragupathi G ,et al. Sequential immunization of melanoma patients with GD3 ganglioslde vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside[J]. Clin Cancer Res,2004,10(14) :4717-4723.
  • 10Chapman PB, Williams L, Salibi N, et al. A phase Ⅱ trial comparing five dose levels of BEC2 anti-idiotypic monoclonal antibody vaccine that mimics GD3 ganglioside[ J ]. Vaccine ,2004,22 (21-22) :2904-2909.

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  • 1何平,张学,赵晓航.三维细胞培养与肿瘤细胞恶性表型研究[J].生命的化学,2005,25(3):252-255. 被引量：2
  • 2唐坚清,张声.血管生成的体外三维培养[J].国际病理科学与临床杂志,2005,25(4):320-323. 被引量：1
  • 3Me|illo G,Semenza G L. Meeting Report: Exploiting the tumor microenvironment for therapeutics [ J ]. Cancer Res, 2006,66 ( 9 ) : 4558 - 60.
  • 4Wang R, Xu J, Juliette L, Castilleja A. Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone [ J ]. Semin Cancer Biol,2005,15 ( 5 ) :353 - 64.
  • 5Kim J B, Stein R, O'Hare M J. Three-dimensional in vitro tissue culture models of breast cancer-a review [ J ]. Breast Cancer Res Treat, 2004,85 ( 3 ) : 281 - 91.
  • 6Alavi A, Stupack D G. Cell survival in a three-dimensional matrix[J].Methods Enzymol,2007,426:85 - 101.
  • 7Glinsky V V,Huflejt M E, Glinsky G V, Deutscher S L. Effects of Thomsen-Friedenreich antigen-specific peptide P-30 on beta-galactoside-mediated homotypie aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells[ J]. Cancer Res ,2000,60( 10 ) :2584 - 8.
  • 8Yuhas J M,Li A P,Martinez A O,Ladman A J. A simplified method for production and growth of muhicellular tumor spheroids [ J ]. Cancer Res, 1977,37:3639 - 43.
  • 9Sutherland R M,Inch W R, McCredie J A, Kruuv J. A multi-component radiation survival curve using an in vitro tumor model [ J ].Int J Radiat Biol Relat Stud Phys Chem Med, 1970,18 (5) :491 - 5.
  • 10Hutmacher D W, Sittinger M, Risbud M V. Scaffold-based tissue engineering: rationale for computer-aided design and solid free- form fabrication systems [ J ]. Biotechnology, 2004,22 ( 7 ) : 354 - 62.

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现代诊断与治疗
2006年 第1期

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