摘要
用尼龙线栓塞法造成大脑中动脉(MCA)缺血模型的大鼠。2h后,尾静脉给予羟基红花黄色素A(1、2和4mg/kg)、尼莫地平(2mg/kg)或生理盐水。4h后取出尼龙线,得到局灶性缺血-再灌注模型。于缺血24h后观察的结果表明,相较于生理盐水组,中、高剂量羟基红花黄色素A可显著改善大鼠的神经学缺陷,减小脑梗死区比例,低剂量组仅可改善大鼠的神经学缺陷。各剂量组疗效均优于尼莫地平。病理组织学检查结果表明,各剂量组可略缓解梗死区神经细胞坏死情况。
Focal cerebral ischemia model was established by using nylon line occlusion of the middle cerebral artery of rats. Hydroxysaffior yellow A （1, 2 and 4mg/kg）, nimodipine （2mg/kg） and saline were administrated by caudal vein injection after ischemia for 2h. The focal cerebral ischemia-reperfusion model was obtained by taking out the nylon line after 4h. The neurological deficit, the ratio of cerebral infarction area to total brain area and pathological histological changes of cerebral infarction were investigated after ischemia for 24h. The results showed that compared with the saline group, the middle and high dosage groups of hydroxysaffior yellow A could significantly improve the neurological deficit and decrease the ratio of cerebral infarction, low dosage group could only improve the neurological deficit. The therapeutic effects of the three groups were better than nimodipine group. The results of pathological histological examination showed that hydroxysaffior yellow A could modify the cellular necrosis status.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第2期104-106,共3页
Chinese Journal of Pharmaceuticals
