摘要
目的评价黄豆苷元胶囊治疗围绝经期综合症的有效性。方法60例围绝经期妇女随机分为黄豆苷元组(32例)和对照组(28例),黄豆苷元组口服黄豆苷元胶囊150mg·d-1,对照组口服倍美力片0.625mg·d-1,两组连续治疗3个月。用药前及用药3个月后观察围绝经期征候群,测血清E2,FSH,LH及脂蛋白,并观察药物不良反应。结果两组围绝经期征候群均有显著改善,FSH,LH均显著下降,E2均显著上升,两组比较差异无显著性;两组TC,TG,LDL均有明显下降,HDL略有上升,黄豆苷元组变化略大于对照组,但差异无显著性。胃肠道反应、阴道出血、乳房肿胀发生率黄豆苷元组分别为:12.5%,0,0,对照组分别为:42.9%,75%,21.4%,两组比较有显著差异。结论黄豆苷元胶囊对围绝经期综合征有显著疗效,而且药物副作用小。
Objective To evaluate the effect of daidzein capsules on menopause syndrome. Methods 60 perimenopausal women were divided into daidzein group and control group randomly. There were 32 women in the daidzein group and 28 women in the control group. The daidzein capsules was taken by perimenopausal women in daidzein group with 150 mg-d-1 for three months. The conjugated estrogen was taken in the control group with 0.625 mg.d-1 for three months. Menopause symptom was observed before and after treatment. Serum E2, FSH, LH and lipoprotein were measured at the same time. The adverse reaction was also observed. Results In two group the menopause syndrome were all relieved, Both of them made Serum FSH, LH ,TC,TG,LHL decreased and E2 increased, the varieties of daidzein group were greater than that＇ of control group, but the difference is not notable. The adverse reaction of alimentary canal, bleeding of vagina and tumidness of bubby were 12.5%,0%,0% in daidzein group and 42.9%,75%,21.4% in control group, the difference between two group is prominent. Conclusion The Daidzein capsules was effective in menopause syndrome treatment, and the adverse reaction was slight.
基金
盐城市医药科技发展计划项目(盐科计2004/22号).
