摘要
目的:研究氯沙坦对早期高血压心室肥厚和左室舒张功能的影响。方法:测定治疗前后血浆肾素活性、血管紧张素Ⅱ、醛固酮含量。左心室肥厚指标及心肌舒张功能用彩色多谱心动仪测定。结果:治疗8周后血浆醛固酮及血清Ⅲ型前胶原的含量降低,快速充盈峰速(E)与心房收缩峰速(A)之比升高,而室间隔厚度(IV S)、左室后壁厚度(PW T)及左室心肌重量指数(LVM I)治疗前后未见明显变化。结论:氯沙坦在有效降低血压的同时,具有明显的改善左心舒张功能的作用。
Objective To investigate the effect of losartan on left ventricular hypertrophy and left ventricular diastolic function in hypertension. Methods Thirty two essential hypertension patients （WHO classⅡ）were treated with losartan for eight weeks. Plasma renninactivity, angiotensinⅡ （Ang Ⅱ）,aldosterone and procolagen Ⅲ were determined. The left ventricular mass and ventricular function were monitored by color Doppler cardiography. Results Levels of aldosterone were decreased significantly. The ratio of peak velocity was increased at rapid filling（E） and atrial contraction （A）. The thickness of interventricular septum（IVS）and posterior wall, left ventricular mass index did not alter. Conclusion Blood pressure, procolagen Ⅲ and the diastolic function are improved after the treatment by losartan.
出处
《实用诊断与治疗杂志》
2006年第2期111-112,共2页
Journal of Practical Diagnosis and Therapy
关键词
高血压
左室功能
左室肥厚
胶原
氯沙坦
Hypertension
left ventricular function
left ventricular hypertrophy
colagen
losartan
