摘要
探讨ＩｇＡ肾病与乙型肝炎病毒的关系。方法采用免疫组化技术检测ＩｇＡ肾病患者肾组织中ＨＢＶ抗原及Ｓｏｕｒｔｈｅｒｎ印迹分子杂交技术检测肾组织中ＨＢＶＤＮＡ。结果８５例ＩｇＡ肾病患者血清ＨＢｓＡｇ阳性１５例（１７．６５％），肾组织ＨＢＶ抗原阳性２６例（３０．５９％），其中肾小球阳性１８例（５７．１４％），ＨＢｃＡｇ在肾小管和肾间质中阳性分别为９例（３４．６７％）和２例（７．６９％）；２例测肾组织ＨＢＶＤＮＡ，１例阳性；肾组织ＨＢＶ抗原阳性组比阴性组临床和病理改变更严重。
bjectiveToclarifytherelationshipbetweenIgANandHBV.MethodsHBVantigensinrenalbiopsyspec-imenswithIgANweredetectedbyimmunohistochemicaltechniqus,HBVDNAofrenaltissueswereanalyzedbysouthernblothybridizationtechnique.ResultsIn85patientswithIgAN,HBsantigenemiawasdetectedin15pa-tients(17.65%),HBVantigensinrenalbiopsyspecimensweredectectedin26patients(30.59%),positiverateofHBVantigensinglomeruliwas57.14%(18/26).HBcAgwasalsofoundintubularepitheliaandinterstitium,re-spectively34.62%(9/26)and7.69(2/26).PresenceandstateofHBVDNAofrenaltissueswereanalyzedin2cases,HBVDNAwasprovedin1case.WhencomparingtheclinicalandpathologicalchangesintheHBVmarkerpositivegroupwiththenegativegroup,thepositivegroupwasmoreobviousandsevere.ConclusionHBVmayplayasignificantpathogeneticroleinthedevelopmentofIgAN.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第5期276-278,共3页
Chinese Journal of Nephrology
关键词
IGA
肾病
乙型肝炎病毒
抗原
IgANephropathyHepatitisBvirusHBsAgHBcAgHBeAg
