摘要
为了进一步了解乙型肝炎病毒（ＨＢＶ）在成人膜性肾病（ＭＮ）发病中的作用。作者应用免疫组化方法对６７例ＭＮ，患者肾组织中的ＨＢＶ抗原进行了检测。年龄小于３０岁者２６例，３０～５０岁者３２例，大于５０岁者９例。肾组织中ＨＢＶ抗原检出率分别是７３．１％（１９／２６），７５％（２４／３２）和３３．３％（３／９）。５０岁以上ＭＮ患者肾组织中ＨＢＶ抗原检出率显著低于５０岁以下年龄组（Ｐ＜０．０５）。ＭＮ患者肾组织中以ＨＢｓＡｇ检出串最高，６７．２％（４５／６７），ＨＢｃＡｇ检出率２２．４％（１５／６７），ＨＢｅＡｇ仅１例阳性；ＨＢＶ抗原总阳性率６８．７％（４６／６７）。以３０例系膜增殖性肾炎（ＭｓＰＧＮ）为对照，ＨＢｓＡｇ检出率１０％（３／３０），ＨＢｃＡｇ、ＨＢｅＡｇ均为阴性。ＨＢＶ抗原总阳性率１０％（３／３０）。ＭＮ组肾组织内ＨＢＶ抗原检出率显著高于ＭｓＰＧＮ组（Ｐ＜０．０１）。本研究结果显示，ＨＢＶ抗原及其相应抗体形成的免疫复合物在膜性肾病，特别是中青年患者的发病机理中起着极其重要的作用，其中ＨＢｓＡｇ可能是最主要的致病抗原。
o investigate the role of hepatitis B virus in thepathogenesis of membranous
nephropathy (MN) inChina, we studied 67 MN patients (excluding lupasnephritis V) with
immunoperoxidase technique. In 46(68. 2%) of the 67 MN patients, HBV antigens (HB-sAg,
HBcAg and HBeAg) were detected in theirglorneruli , and HBsAg, the dominant antigen was
de-tected in 45 patients (67. 2%). HBV-Ag was detectedless frequently in the older MN group (33.
3%) (>50years old) than in the two younger MN groups(73. 1% , 75%) (<30 years old , 30-50
years old) (P< 0. 05). 30 randomly selected MsPGN patients werestudied as controls. HBV
antigens were detected in on-ly 3 out of the 30 MsPGN patients. The HBV antigenpositivity rate
of the MN group was significantly higherthan that of the MsPGN group (P<0. 01). The re-sults
suggested that HBV may be the main cause ofMN in China, especially in those younger than
50years, but not of MsPGN. HBsAg containing immunecomplexs (IC) may play an important role
in thepathogenesis of HBV-MN.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第9期540-542,I051,T001,共5页
National Medical Journal of China
基金
卫生部科研基金
