摘要
目的:观察自拟中药汽疗薰蒸方治疗类风湿性关节炎的临床疗效,以及对患者免疫功能的调节。方法:共选入150例类风湿性关节炎患者,为2002-01/2005-01哈尔滨医科大学附属第一医院中西医结合科住院患者,随机分为治疗组100例和对照组50例。治疗组患者进行中药汽疗(方药组成:制川乌15kg,制草乌15kg,乌梢蛇1条,全蝎5g,蜈蚣2条,威灵仙20g,海风藤20g,伸筋草20g,透骨草20g,羌活15g,独活15g,防已15g,地龙15g,鸡血藤25g),1次/d,30min/次;对照组患者给予常规抗类风湿性关节炎药物治疗:青霉素静脉滴注,1次/d,同时口服西乐葆片,200mg/次,2次/d,治疗1个疗程(10d)后,观察两组患者的临床症状中关节肿胀、疼痛、压痛、晨僵和功能障碍的改善情况,并对主要指标血沉、类风湿因子、C反应蛋白、免疫球蛋白(IgA,IgG)等进行评估和监测。结果:参选的150人全部完成数据采集,无脱落者。①两组疗效比较:治疗组总有效率优于对照组(94%,66%,P<0.01)。②治疗后症状体征各运动功能评分:治疗组关节疼痛度、关节压痛度、活动度、肿胀度、晨僵时间均低于对照组[(0.92±0.56),(1.19±0.60)分;(3.13±1.89),(4.21±2.42)分;(0.54±0.43),(0.98±1.44)分;(4.46±2.80),(8.05±3.28)分;(18.52±10.23),(24.78±11.21)min,P<0.01]。③治疗后实验室指标变化:治疗组血沉、类风湿因子、C反应蛋白、IgA、IgG均低于对照组[(25.15±14.28),(46.23±14.59)mm/h;(29.43±15.98),(46.44±19.67)滴度;(14.57±8.90),(19.43±10.12)mg/L;(2.16±1.40),(2.98±1.95)g/L;(14.82±4.37),(18.94±5.51)g/L,P<0.01]。结论:中药汽疗治疗类风湿性关节炎疗效显著,可明显改善人体的免疫功能,且方法简便易行。
AIM： To observe the clinical effect of vapour therapy of Chinese medicine on rheumatoid arthritis（RA）, and its adjusting effect on patients＇ immunological function.
METHODS： A total of 150 inpatrents with RA from the Department of Combination of TCM and Western Medicine, First Affiliated Hospital of Harbin Medical University from January 2002 to January 2005 were randomly divided into treatment group （n=100） and control group（n=50）. Patients in the treatment group received vapour therapy of Chinese medicine （composing of 15 kg common monkshood mother root, 15 kg Radix aconiti Kusnezoffii preparata, one black snake, 5 g scorpion, two centipede, 20 g sixpotal clematis root, 20 g kadsura pepper stem, 20 g staghorn clubmoss herb, 20 g tuberculate speranskia herb, 15 g,forbes notopterygium rhizomer of root, 15 g angelica root, 15 g trilobus, 15 g earth-worm and 25 g suberect spatholobus stem ） once a day and 30 minutes each time; Patients in the control group were treated with routine drugs against RA： Venous injection of penicillin, once a day, meanwhile, celecoxib were taken orally twice a day and 200 mg each time. After a theraputic course （10 days）, the amelioration of clinical symptoms such as joint swelling, pain, tenderness and morning stiffness as well as malfunction of two groups were observed, and main indexes such as erythrocyte sedimentation, rheumatoid factor, C-reactive protein（CRP）, immune globulin （IDA, G were evaluated and monitored.
RESULTS： A total of 150 subjects were involved in the analysis of resuits. No subject withdrew from the study. （1）Comparison of curative effect between the two groups： The total effective rate was higher in the treatrment group than in that the control group（94% ,66% ,P 〈 0.01 ）.（2）The motorfunction scores of symptoms and physical signs after treatment： Joint ache degree, joint tenderness degress, activity, swelling degree and morning stiffness time were lower in the treatment group than those in the control group [（0.92±0.56）,（1.19±0.60） points; （3.13±1.89）,（4.21±2.42） points; （0.54±0.43）,（0.98±1.44） points; （4.46±2.80）,（8.05±3.28） points; （18.52±10.23）, （24.78±11.21 ） min,P 〈 0.01]. （3）Changes of laboratory indexes after treatment： erythrocyte sedimentation, rheumatoid factor, C-reactive protein （CRP）, IgA, LgG in the treatment group were lower than those in the control group. [（25.15±14.28）,（46.23±14.59） mm per hour; （29.43±15.98）, （46.44±19.67） tite; （14.57±8.90）,（19.43±10.12） mg/L; （2.16±1.40）, （2.98±1.95） g/L; （14.82±4.37）, （ 18.94±5.51 ）g/L,P 〈 0.01].
CONCLUSION： Vapour therapy of Chinese medicine has significant effect on RA, it is a simple, safe and feasible method and can improve demic immunological function obviously.
出处
《中国临床康复》
CAS
CSCD
北大核心
2006年第3期24-26,共3页
Chinese Journal of Clinical Rehabilitation
