摘要
目的:观察冠脉内支架置入术后低分子肝素和普通肝素的临床疗效。方法:将研究对象49例分为普通肝素组22例及低分子肝素组27例。观察两组急性、亚急性支架内血栓形成发生例数及术后半个月内严重心脏事件的发生情况。统计两组出血副作用的发生例数。结果:低分子肝素组发生急性、亚急性支架内血栓形成及术后半个月内心脏严重事件的发生例数均低于普通肝素组,但无统计学差异(P>0．05)。低分子肝素组出血发生率明显低于普通肝素组(P<0．05)。结论:低分子肝素抗凝疗效与普通肝素相似,而出血事件明显少于普通肝素,且无需监测,值得推广应用。
Objective： To compare the clinical effects of low molecular weight heparin and heparin after coronary artery stent implantation. Method： Forty-nine patients with coronary artery stent implantation were divided into heparin group 22 cases and low molecular weight heparin （LMWH） group 27 cases. The cases of acute and subacute intrastent thrombosis and the cases of severe cardiac events in one half month after operation were observed. The cases of bleeding were analyzed too. Result： The numbers of acute and subacute intrastent thrombosis and severe cardiac events in one half month after operation in group treated with LMWH were less than that in group treated with heparin ,but there were no statistic differences（ P 〉 0.05 ） in two groups. The cases of bleeding in LMWH group were lower than that of heparin group obviously, there were statistic differences（ P 〈 0.05 ）. Conclusion： The effects of anticoagulation of LMWH is similar with heparin ,the bleeding events of LMWH is less than heparin obviously. The using of LMWH without need of monitor, so LMWH is worthy to be used widely.
出处
《中国药师》
CAS
2006年第2期108-110,共3页
China Pharmacist
关键词
低分子肝素
肝素
支架植入
支架内血栓形成
Low molecular weight heparin
Heparin
Stent implantation
Intrastent thrombosis
