摘要
六价铬眼Cr(VI)演是一种公认的环境化学毒物,可导致多种类型的DNA损伤。但其本身并不能直接作用于DNA,它以氧阴离子形式通过非专一性的磷酸/硫酸阴离子通道透过细胞膜后经细胞内的还原剂还原形成一系列低价态铬,如五价铬眼Cr(V)演、四价铬眼Cr(IV)演和三价铬眼Cr(III)演。该文主要对Cr(VI)化合物进入体内后如何引起DNA损伤及DNA损伤类型作一概述。
Hexavalent chromium [Cr （Ⅵ）] is a well-know environmental toxicant which can cause many types of DNA damage. However Cr（Ⅵ） does not react directly with DNA itself, it penetrates the cell membrane through the nonspeeific phosphate/ sulphate anion channel and undergoes a reductive metabolism to a series of lower oxidation state including quinquevalent ehromium[Cr（Ⅴ）], quadrivalent chromium [Cr （Ⅳ）] and trivalent chromium[Cr（Ⅲ）]. Cr（Ⅲ） can form variety of Cr-DNA adducts; moreover oxidative Cr （Ⅴ） and free radicals generated during the reduction cause DNA oxidative damage. The process of how Cr （Ⅵ.） induce DNA damage after entered the cells and types of DNA lesions were briefly reviewed in the present article.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2006年第1期93-96,共4页
Journal of Environment and Health
基金
国家自然科学基金资助项目(20137010)
关键词
铬
DNA损伤
自由基
碱基氧化
Chromium
DNA Damage
Free radicals
Base oxidation
