摘要
目的:观察宁心滴丸对大鼠急性心肌缺血的影响。方法:采用结扎大鼠冠状动脉左前降支建立急性心肌缺血模型,观测宁心滴丸对急性心肌缺血大鼠心电图、心肌梗死范围、肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓素(TXB2)及6-酮-前列环素(6-Keto-PGF1a)的影响。结果:宁心滴丸能显著抑制急性心肌缺血大鼠心电图J点升高,减小心肌梗死范围,降低CK、LDH、MDA及TXB2水平,升高SOD6、-Keto-PGF1a水平。结论:宁心滴丸对大鼠急性心肌缺血具有保护作用。
Objective：To observe the protective effects of NingXinDiWan（NXDW） on acute myocardial infarction in rats. Methods ： The model acute myocardial infarction of rat was induced by ligating anterior branch of the left coronary artery. The change of ECG, and the level of CK, LDH, SOD, MDA, TXB2,6-keto-PGF1a were determined, the infarction area of myocardium was also observed. Results： NXDW could obviously refrain the elevated J of ECG, decrease the infarction area of myocardium, reduce the level of CK,LDH,MDA and TXB2, and increase the level of SOD and 6-keto- PGF1a, Conclusion：NXDW can protect myocardium from injury induced by ligating anterior branch of left coronary artery in rats.
出处
《中国实验方剂学杂志》
CAS
2006年第1期36-38,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
宁心滴丸
急性心肌缺血
肌酸激酶
乳酸脱氢酶
脂质过氧化
血小板功能
NXDW
Acute myocardial infarction
Creatine kinase
Lactic acid dehydrogenase
Lipid preoxidation
Platelet funtion
