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新生儿脐血脂联素水平及与其他相关激素间关系研究 被引量：7

Adiponectin concentration of cord blood and its relationship with other related hormones in neonates
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摘要 目的探讨新生儿脐血脂联素水平及与脐血瘦素、胰岛素、甲状腺激素、生长激素间的关系.方法采用放射免疫法检测78例正常足月新生儿脐血脂联素、瘦素、胰岛素、甲状腺激素、生长激素水平,所有新生儿分为小于胎龄儿(SGA)13例、适于胎龄儿(AGA)53例、大于胎龄儿(LGA)12例,并计算体重指数=体重(kg)/身长2(cm2)评估新生儿营养状态.结果新生儿脐血脂联素水平为(24.58±4.26)μg/ml,与体重指数呈正相关(r=0.367,P＜0.05);SGA组脐血脂联素为(19.95±4.70)μg/ml,AGA组(24.81±4.15)μg/ml,LGA组(26.57±4.29)μg/ml,3者间差异显著(F=8.871,P＜0.05);新生儿不同性别、分娩方式间脂联素水平差异无显著性(t=1.314,0.713,P均＞0.05);脐血脂联素与瘦素、胰岛素、FT3、FT4呈正相关(r=0.298～0.453,P均＜0.05);与TSH呈负相关(r=-0.487,P＜0.05);与生长激素、TT3、TT4无相关性(r=0.072、0.182、0.211,P＞0.05).结论新生儿脐血脂联素水平为(24.58±4.26)μg/ml,在一定程度上反映了胎儿的营养状态,它可能与瘦素、胰岛素、甲状腺激素一起共同调节胎儿的生长发育,它们可以作为评估胎儿体重与生长发育的临床指标. Objective To investigate adiponectin concentration in the cord blood and its relationship with other related hormones in neonates. Methods The concentrations of adiponectin, leptin, insulin, thyroid hormone and growth hormone were measured in 78 normal newborns by radioimmunoassay（RIA） .All newborns were divided into SGA（13）, AGA（53）and LGA（12）groups according to birth weight. The body mass index（BMI） was calculated and the neonatal nutritional status was evaluated in each group. Results The concentration of adiponectin in cord blood was 24.58± 4.26 μg/ml in all 78 neonates, 19.95± 4.70 μg/ml in SGA , 24.81 ± 4.15 μg/ml in AGA and 28.57 ± 4.29 μg/ml in LGA respectively. There was a significant difference among three groups （F = 8.871,P〈0.05）. Adiponectin concentration had positive correlations with BMI （ r = 0.367, P〈 0.05）, leptin（ r = 0.326, P〈 0.05）, insulin（r = 0.453, P〈 0.05）, FT3（ r = 0.298, P〈 0.05） and FT4（ r = 0.315, P〈0.05）; but negative correlation with TSH（ r = -0.487, P〈0.05） and no correlation with growth hormone,TT3,TT4 （ r = 0. 072,0.182,0. 211,P〉0. 05）. There was no difference among three groups in different sex and delivery ways（ t = 1. 314, t = 0.713, P 〉0.05）. Conclusions Adiponectin in cord blood that reflects the nutritional status may regulate the development of fetus together with leptin,insulin and thyroid hormone.
作者 田朝霞 李彦敏 范雪爱 闫国超 杜小芳
机构地区 河北医科大学第一医院儿科 河北省藁城市人民医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2005年第11期765-767,共3页 Journal of Clinical Pediatrics
关键词 脐血 脂联素 瘦素 胰岛素 甲状腺激素 生长激素 cord blood adiponectin leptin insulin thyroid hormone growth hormone
分类号 R722.1 [医药卫生—儿科]
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参考文献11

  • 1Lindsay RS, Walker JD, Havel PJ, et al. Adiponectin is present in cord blood but is unrelated to birth weight.Diabetes Care, 2003,26(8): 2244 - 2249.
  • 2Sivan E, Mazaki-Tovi S, Pariente C, et al. Adiponectin in human cord blood: relation to fetal brith weight and gendet. J Clin Endocrinol Metab, 2003,88(12): 5656-5660.
  • 3Kotani Y, Yokota I, Kitamura S,et al. Plasma adiponectin levels in newborn are higher than those in adults and positively correlated with brith weight. Clin Endocrinol, 2004, 61(4): 418 - 423.
  • 4Chan TF, Yuan SS, Chen HS, et al. Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights. Acta Obstet Gynecol Scand,2004, 83(2): 165 - 169.
  • 5卢慧玲,王宏伟,温宇,林汉华.肥胖症儿童血浆脂联素水平测定及临床意义研究[J].临床儿科杂志,2004,22(4):233-235. 被引量：27
  • 6Pardo IM, Geloneze B, Tambascia MA,et al. Hyperadiponectinemia in newborns:relationship with leptin levels and birth weight. Obes Res, 2004,12(3):521- 524.
  • 7Tsai PJ, Yu CH, Hsu SP, et al. Cord plasma concentrations of adipnectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol, 2004,61(1): 88 - 93.
  • 8Yamauchi T, Oike Y, Kamon J, et al. Increased insulin sensitivity despite lipodystrophy in crebbp heterozygous mice. Nat Genet,2002,30(2) :211 - 216.
  • 9Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin:an adipokine regulating glucose and lipid metabolism.Trends Endocrinol Metab, 2001,13(2): 84 - 89.
  • 10Holst JJ, Binderup M. Fatty tissue and insulin resistance: resistin and adiponectin. Ugeskr Laeger, 2002,164(16): 2173 - 2176.

二级参考文献10

  • 1Yang WS, Lee WJ, Funahashi T, et al. Weight reduction increased plasma levels of an aadipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab, 2001, 86(8) :3815- 3819.
  • 2Asayama K, Hayashibe H, Dobashi K, et al. Decrease in serum adiponectin level due to obesity and viseral fat accumulation in children. Obes Res , 2003, 11(9) :1072 -1079.
  • 3Nemet D, Wang P, Funahashi T, et al. Adipocy tokines, body composition, and fitness in children. Pediatr Res , 2003, 53(1): 148- 152.
  • 4Stefan N, Bunt JC, Salbe AD, et al. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Chin Endocrinol Metab, 2002, 87(10) :4652 - 4656.
  • 5Berg AH, Combs TP, Scherer PE, et al. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab, 2002, 13(2):84- 89.
  • 6Shuldiner AR, Yang R, Gong DW. Resistin, obesity, and insulin resistance:the emerging role of the adipocyte as an endocrine organ. N Engl Med, 2001, 345(18):1345- 1346.
  • 7Flier JS. The miss link with obesity?Nature, 2001, 409:292 - 293.
  • 8Shand BI, Scott RS, Elder PA, et al. Plasma adiponectin in overweight , nondiabetic individuals with or without insulin resistance. Diabetes Obes Metab, 2003, 5(5):349 - 353.
  • 9Fortuno A, Rodriguez A, Gomez-Ambrosi J, et al. Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases. J Physiol Biochem, 2003, 59(1): 51 - 60.
  • 10Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes:close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab, 2001,86(5): 1930 - 1935.

共引文献26

同被引文献88

引证文献7

二级引证文献43

临床儿科杂志
2005年 第11期

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