摘要
We report a new method for measuring particle size distribution （PSD） and refractive index of the top layer ill a two-layer tissue phantom simulated epithelium tissue by varying the azimuth angle of incident linearly polarized light. The polarization gating technique is used to decouple the single and multiple scattering components in the returned signal. The theoretical model based on Mie theory is presented and a nonlinear inversion method -floating genetic algorithm - is applied to inverting the azimuth dependence of component of polarization light baekscattered. The experiment results demonstrate that the size distribution and refractive index of the scatters of the top layer can be determined by measuring and analyzing the differential signal of the parallel and perpendicular components from a two-layer tissue phantom. The method implies to detect precancerous changes in human epithelial tissue.
We report a new method for measuring particle size distribution （PSD） and refractive index of the top layer ill a two-layer tissue phantom simulated epithelium tissue by varying the azimuth angle of incident linearly polarized light. The polarization gating technique is used to decouple the single and multiple scattering components in the returned signal. The theoretical model based on Mie theory is presented and a nonlinear inversion method -floating genetic algorithm - is applied to inverting the azimuth dependence of component of polarization light baekscattered. The experiment results demonstrate that the size distribution and refractive index of the scatters of the top layer can be determined by measuring and analyzing the differential signal of the parallel and perpendicular components from a two-layer tissue phantom. The method implies to detect precancerous changes in human epithelial tissue.
基金
This work was carried out at the Key Laboratory of Biomedical Photonics of Ministry of Education,Huazhong University of Science and TechnologyThis research was supported by the National Natural Science Foundation of China (No. 30470460 and 60278017)
