摘要
目的:制备双氯芬酸钠贴片,研究其体外释放、透皮吸收性能。方法:制备以聚丙烯酸酯为骨架的双氯芬酸钠贴片,以蛇皮为模型,采用改进Franz扩散池考察药物经皮渗透性能,并按中国药典方法考察了贴片的体外释放性能。结果:双氯芬酸钠贴片体外释放速率为21.98μg·cm-2·h-1/2,体外透皮速率为17.97μg·cm-2·h-1/2。结论:双氯芬酸钠贴片释放度曲线及24h累计渗透量均符合Higuchi方程,是一种新颖的缓释型外用制剂。
OBJECTIVE To prepare the diclofenac sodium patch and study its characteristics of transdermal delivery. METHODS Methacrylic acid copolymer was employed to prepare declofenac sodium patch. Snake skin and modified Franz diffusion cells were used in the drug penetration tests. The release test was performed using the method of the Chinese pharmacopoeia. RESULTS The release rate of diclofenac sodium patch was 21.98μg·cm^-2·h^-1/2, the penetration rate in vitro was 17. 97μg·cm^-2·h^-1/2. CONCLUSION The release rate and the penetration in vitro of diclofenac sodium patch accorded with the Higuchi equation. Diclofenac sodium patch was developed.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第8期738-738,739,740,共3页
Chinese Journal of Hospital Pharmacy
关键词
双氯芬酸钠
释放度
体外渗透
diclofenae sodium
release rate
in vitro permeation
