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与帕金森病相关的致病基因研究进展 被引量：1

Progress of Study on Pathogenic Gene Associatedwith Parkinson Disease
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摘要 帕金森病是一种神经系统变性疾病,路易小体(LB)是帕金森病典型的病理改变,某些基因的变异将会导致帕金森病的发生,目前已经确定的基因有α-synuclein、Parkin、UCHL1。这3种基因均能通过影响泛素-蛋白体系统(UPS)的功能来导致帕金森病的发生。就3种基因的变异与泛素-蛋白体系统之间的相互关系作一综述。 Parkinson disease is a kind of neurodegenerative disease. The classic pathological finding of Parkinson disease is Lewy body （LB）. Certain genie mutation would induce Parkinson disease, such as α-synuclein, Parkin, UCHL1 which are ascertained to be associated to Parkinson disease. These gene mutants damage the ubiquitin-proteasomes system（UPS）, the UPS dysfunction would lead to Parkinson disease. This review focuses the relationship between the three gene mutant action and the ubiquitin-proteasome system.
作者 彭继英 孙异临
机构地区 首都医科大学北京市神经外科研究所
出处 《首都医科大学学报》 CAS 2005年第6期765-768,共4页 Journal of Capital Medical University
基金 北京市自然科学基金(7012009)资助项目
关键词 基因研究进展 帕金森病 神经系统变性疾病 泛素-蛋白 病理改变 路易小体
分类号 R725.622.5 [医药卫生—儿科] R742.5 [医药卫生—神经病学与精神病学]
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参考文献21

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首都医科大学学报
2005年 第6期

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