摘要
目的：研究增殖细胞核抗原（ＰＣＮＡ）与胃癌淋巴结转移的关系和意义．方法：采用ＡＢＣ免疫组织化学染色法对４４例经福尔马林固定、石蜡包埋的胃癌手术标本进行半定量检测，观察ＰＣＮＡ与淋巴结转移和胃癌组织学类型的关系．结果：伴淋巴结转移组ＰＣＮＡ高表达者占７６．２％（１６／２１），显著高于无转移组１３％（２／２３），两者呈显著相关联（Ｐ＜０．０５）．低分化型胃癌ＰＣＮＡ高表达者６８．４％（１３／１９）显著高于高、中分化型胃癌２４％（６／２５），Ｐ＜０．０１．结论：ＰＣＮＡ表达强者，淋巴结转移发生率高。
Objective: To study the correlation between proliferating cell nuclear antigen (PCNA) and lymph node metastasis of gastric carcinoma. Methods: Formalin fixed, paraffin embedded, surgically resected tissue specimens of 44 gastric carcinoma were investigated by ABC immunohistochemical staining. Lymph node metastasis and histological grade were examined. Results: The PCNA expression in both cases of lymph node metastasis (76%, 16/21) and poorly differentiated gastric carcinoma (68.4%, 13/19) were significantly higher than in those without metastasis (13%, 3/23) ( P <0.05), and in well/moderately differentiated type (24%, 6/25) ( P <0.01). Conclusion: The presence of PCNA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis. These data suggest that PCNA is a fairly good index to indicate lymph node metastasis of gastric carcinoma.
出处
《第四军医大学学报》
1996年第3期169-171,共3页
Journal of the Fourth Military Medical University
关键词
增殖细胞核抗原
胃肿瘤
淋巴结
转移
proliferating cell nuclear antigen stomach neoplasms lymph node metastasis
