摘要
目的探讨血浆高同型半胱氨酸(Hcy)血症与急性心肌梗死(AM I)预后的关系。方法102例AM I患者分为高Hcy血症AM I组及Hcy正常AM I组,比较两组临床事件(泵衰竭、休克、心律失常、死亡)发生情况及梗死面积等。同时选择健康体检者25例为正常对照组,检测Hcy浓度并与AM I患者进行比较。结果AM I患者血浆Hcy浓度〔(28.29±5.14)μmol/L)〕明显高于正常对照组〔(10.66±2.75)μmol/L)〕(P<0.01);高Hcy AM I组梗死面积、病死率、心律失常、休克及泵衰竭发生率均高于Hcy正常AM I组(P<0.05);冠脉造影显示高Hcy血症与病变血管总数成正相关;多元回归分析表明高Hcy血症是强的心血管事件发生的预测因子(P<0.05)。结论高Hcy血症的AM I患者临床事件发生率明显增多,血管病变程度较Hcy正常者严重,高Hcy血症是AM I心血管事件发生的预测因子。
Objective To investigate the relationship between hyperhomocysteinemia and prognosis of patients with acute myocardial infraction （AMI）. Methods Plasma homoeysteine （Hcy） concentration was measured in 102 patients with AMI [ averagely aged （58.1 ± 9.0） years old]. Plasma Hey level exceeded 15 μmol/L was hyperhomoeysteinemia. The patients were divided into hyperhomoeysteinelnia AMI group and normal Hey AMI group to compare the occurrence of clinical accidents （pump failure, shock, arrhythmia and death） and infarction size. Hey concentration of 25 healthy controls were detected to compare with that of AMI patients. Results Hey level in AMI group was higher [ （28.29 ±5.14 ） μmol/L] than that in control group [ （10.66 ± 2.75）μmol/L] （P 〈 0.01 ）. The infarction size, fatality rate, occurrence rate of arrhythmia, shock and pump failure in hyperhomocysteinemia AMI group were higher than those of normal Hcy AMI group （ P 〈 0.05 ）. The results by coronary angiography showed that the number of obstructed arteries was proportionate to the level of hyperhomocysteinemia. Multiple regressive analysis demonstrated that hyperhomocysteinemia was a predictive factor of attack of cardiovascular accidents （P 〈 0.05）. Conclusions Hcy level in AMI group was clearly higher that that in controls; the incidence of clinical accidents increased clearly and the vascular pathological change degree in the AMI patients with hyperhomocysteinemia was more serious than that of normal Hey AMI group. Hyperhomocysteinemia should be a predictive factor of attack of cardiovascular accidents.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2005年第12期1455-1457,共3页
Chinese Journal of Gerontology
基金
吉林省科技厅基金资助课题(20030419)
关键词
急性心肌梗死
同型半胱氨酸
临床状况
Acute myocardial infarction （AMI）
homocysteine（HCY）
Clinical accidents
