摘要
目的以卡托普利舌下含服治疗高血压急症，并与利血平肌注治疗对照。方法卡托普利３７．５ｍｇ舌下含服治疗高血压急症６０例为治疗组，６０例用利血平１．０ｍｇ肌注作对照。结果卡托普利组用药后１５ｍｉｎ即开始有显著的降压作用（Ｐ＜０．００１），３０，６０，１２０ｍｉｎ后疗效更显著（Ｐ＜０．００１）。对照组利血平用药后１５ｍｉｎ血压无显著下降（Ｐ＞０．０５），３０，６０，１２０ｍｉｎ血压明显下降（Ｐ＜０．００１）。二组比较，卡托普利组降压作用明显（Ｐ＜０．００１）。结论卡托普利舌下含服是治疗高血压急症较迅速、有效、安全、简便的降压方法。
AimToinvestigatethetherapeuticalefectofsublingualcaptopilinhypertensi
veemergen-cy.MethodsWerandomlyassigned120patientswithhypertensiveemer
gencytotreatmentwith37.5mgofsublingualcaptoprilor1.0mgofintramuscular
reserpineonce,respectively.ResultsAscomparedwithreserpine,captoprilgr
oupobtainedsignificantantihypertensiveefects(P<0.001),initiatingat15m
in(P<0.001)reachingfurtherbenifits30,60,120minaftersingledosewasgiven
(P<0.001).Inthecontrolgroupnoobviousanti-hypertensiveefectswasfound15
minaftertheinjectionofreserpine(P>0.05).However,significantantihypert
ensiveefectsofreserpinewasobtainedonly30,60,120minafterinjection.Conc
lusionSublingualcaptopriltreat-mentisarapid,efective,safeandsimplethe
rapywithminimalside-efectsinpatientswithhyperten-siveemergency.
出处
《高血压杂志》
CSCD
1996年第3期232-233,共2页
Chinese Journal of Hypertension
