摘要
方法采用血管紧张素转换酶抑制剂培哚普利(P)与双氢克尿塞(H)对照进行随机单盲试验,对42例高血压性左室肥大患者治疗观察12周。结果 P 和 H 均能显著降低收缩压和舒张压(P<0.001);P 组治疗后室间隔厚度减少了16.22±3.34%,左室心肌重量指数(LVMI)下降了18.44±6.03%,表明培哚普利通过消退室间隔肥厚而减轻左室重量;H 组治疗后左室舒张末期内径减少了7.34±2.57%,LVMI 下降了10.38±6.44%,表明双氢克尿塞通过缩小左室腔径而使左室重量减轻,但对左室肥厚消退不明显。P 组治疗后颈动脉阻力指数下降了2.59±0.28%。全血粘度降低12.80±3.51%,血小板聚集率下降42.59±9.72%。结论培哚普利能降低血压,逆转左室肥大,改善左心舒张功能和减缓动脉硬化,并能降低血液粘度和血小板聚集率,从而发挥心血管保护作用。
Aim To investigate the effects of perindopril treatment in cardiovascular system of hy- pertensive patients.Methods Fourty two hyper- tensive patients treated with perindopril and hy- drochlorothiazide 12 weeks.Left ventricular hyper- trophy was determined.Carotid artery resistence de- termined by Doppler uhrasonograph.Relative blood viscosity and platelet aggregation rate were examined as well.Results Perindopril reduced septal wall thickness(LVST)and left ventricular mass index (LVMI)by 16.22±3.34% and 18.44±6.03%,re- spectively.Perindopril reduced carotid artery re- sistence index(RI),relative blood viscosity(RBVH) and platelet aggregation rate by 2.59±0.28%,12.80 ±3.51% and 42.95±9.72%.Conclusion Perindopril can reduce blood pressure,reverse LVH, improve LV diastolic function and arteriosclerosis, decrease blood viscosity and platelet aggregation rate.
出处
《高血压杂志》
CSCD
1996年第2期144-146,共3页
Chinese Journal of Hypertension
基金
国家自然科学基金(39270328)
关键词
培哚普利
高血压
左心室舒张功能
血液粘度
perindopril
left ventricle hypertro-phy
diastolic function
carotid artery hemodynam-ics
blood viscosity
