摘要
对消化内科病房181例病人进行了为期7个月的药物不良反应(ADRs)集中监测。出现ADRs58例,96例次,总发生率为32.0％。ADRs累及消化系最多,其次为神经和皮肤,症状以恶心呕吐、腹痛、皮肤瘙痒及皮疹多见。使用的145种药物中37种引起ADRs,消化系统药占首位,31.3％(30/96)。发现ADRs病人的用药种数及次数显著高于非ADRs病人(P<0.01)。肝硬化和溃疡病病人ADRs发生率较高,肝功能中重度不良者ADRs发生率高于肝功能正常者(P<0.05)。提示疾病和药物可能是两个主要因素。
Adverse drug reactions (ADRs) monitoring for 181 patients of digestive medical ward have been made during seven months. ADRs 58 cases and 96 times were discovered. The ADRs incident rate was 32. 0%. Digestive system was effected the most by ADRs and nervous system and skin the second. The common ADRs symptoms were nausea, vomiting, abdominal pain, skin scratch and skin rash. 145 kinds of drug were used in 181 patients, and 37 kinds of drug were related to ADRs. The frequency of digestive drugs was the highest, 31. 3% (30/96). The kinds and times of using drugs of ADRs group was higher than non-ADRs group (P<0. 01). The ADRs incident rates of liver cirrhosis and gastric ulcer patients were more high. The ADRs incident rate of patients with middle and serious degree of unnormal liver function was higher than the normal liver function patients' (P<0. 05). It was suggested thrat diseases and drugs were primary factors.
出处
《药物流行病学杂志》
CAS
1996年第3期139-142,共4页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金资助课题
关键词
监测
消化系统疾病
药物副作用
Adverse drug reactions
Monitoring
Digestive system disease
