摘要
应用高效液相色谱法（ＨＰＬＣ）检测４２例正常人，２４例肾功能正常之慢性肾炎，１２例慢性肾炎肾功能不全氮质血症期患者及２１例尿毒症期患者尿ＦＰＡ水平，其均值分别为：２５．４０±１０．３０ｎｇ／ｍｇＣｒ、２６．９９±５．７７ｎｇ／ｍｇＣｒ、３８．８１±６．２８ｎｇ／ｍｇＣｒ、７９．７４±１８．７６ｎｇ／ｍｇＣｒ。结果显示：氮质血症期组尿ＦＰＡ水平明高于正常对照及肾功能正常之慢性肾炎组（Ｐ＜０．０１），尿毒症期组尿ＦＰＡ显著高于氮质血症期组（Ｐ＜０．０１）。监测尿ＦＰＡ水平与血浆肌酐浓度显示二者呈正相关性（ｒ＝０．９１２０，Ｐ＜０．０１）。揭示，慢性肾炎肾功能不全患者循环血液处于异常高凝状态，其严重程度与疾病的发生、发展密切相关，监测其尿ＦＰＡ水平能较敏感地反映肾功能状态。
The assay of the level of urinary FPA by high performance liquid chromatography(HPLC）in 42 normal controls,57 cases of chronic glomerulo-nephritis(chronic nephritis),including 24 normal renal function,12 deficient renal function,21 uremia.Their values were 25.40±10.30ng/mg.Cr,26.99±5.77ng/mgCr,38.80±6.28ng/mgCr,79.74±18.76ng/mgCr.The level of urinary FPA in deficient renal function group was higher significantly than that of the control group and normal renal function group(P＜0.01),The uremia presented higher dramatically level of urinary FPA than the deficient function group(P＜0.01).We examined the relationship between the level of urinary FPA and the blood creatinin,There was a positive correlation between them(r=0．9120,P＜0.01).It showed that there is hypercoagulable statexisting in the patients.The level of urinary FPA was also a good marker of renal function.
出处
《临床血液学杂志》
CAS
1996年第2期68-70,共3页
Journal of Clinical Hematology
基金
国家八五攻关资助项目
