摘要
研究表明，怀牛膝总皂甙（ＡＢＳ０．１～０．４ｍｇ／ｍｌ）对离体大鼠子宫产生明显的浓度依赖性兴奋作用，５－ＨＴ（１０μｇ／ｍｌ）可明显增强ＡＢＳ的作用。ＡＢＳ和５－ＨＴ均使高Ｋ＋去极化后的高体大鼠子宫产生依细胞内Ｃａ２＋性和依细胞外Ｃａ２＋性收缩；氯两嗪（０．５μｇ／ｍｌ）或氟丙嗪（０．４μｇ／ｍｌ）和消炎痛（２０μｇ／ｍｌ）合用均明显拮抗ＡＢＳ的作用。
The effects of Achyranthes bidentata saponins (ABS) on isolated ratuterus were observed. ABS(0. 1 ￣0. 4mg/ml) usually caused a conspicuously stimulationon rat uterus by dose-dependent and this action was enhanced by 5-HT(10g/ml). Whenisolated uterus were depolarized with the solution of high-K+ and zero-Ca2+, ABS and 5HT could induced C-dependent and C-dependent contraction of uterus. This actionwas blocked significantly by the uterine segments pretreated with chlorpromazine(0. 5g/ml) or chlorpromazine and indomethacin.
出处
《西北药学杂志》
CAS
1996年第4期160-162,共3页
Northwest Pharmaceutical Journal
关键词
怀牛膝总皂甙
5-HT
氯丙嗪
大鼠
子宫平滑肌
Achyranthes bidentata saponins, 5-HT, isolated rat uterus, chlorpromazine, indomethacin
