摘要
目的:观察还原性谷胱甘肽(GSH)对病毒性肝炎的疗效。方法:106例病毒性肝炎患者随机分为A组(治疗组)、B组(对照组),分别用GSH和门冬氨酸钾镁治疗,疗程均为4周。结果:GSH对治疗急、慢性病毒性肝炎的乏力有效率分别为94.4%(17/18)、88.7%(31/35),对钠差的有效率分别为88.9%(16/18)、85.7%(30/35),与对照组比较有显著性差异(P<0.05)。治疗组急、慢性肝炎患者的血清总胆红素(STB)、血清结合胆红素(SCB)、总胆汁酸(TBA)、血清谷丙转氨酶(ALT)、血清谷草转氨酶(AST)的降幅明显高于对照组(P<0.05),慢性肝炎的白蛋白(ALB)在治疗后增高也有显著性差异(P<0.05),ALT、AST的复常率也显著高于对照组(P<0.05)。结论:GSH对病毒性肝炎的疗效较好,优于门冬氨酸钾镁。
Objective：To observe the efficacy and safety of glutathione in the treatment of viral hepatitis. Methods： In the series, 106 patients with viral hepatitis were randomly divided into groups A and B. Patients in group A received glutathione for four weeks,patient in group B received potassium magnesium aspartate for four weeks. Results：In Group A,at the end of treatment ,the effective rate for tired and anorexia in patients with actue hepatitis were94.4% and 88. 9% ,respectively,in patients with chronic hepatitis were 88.7% ,85.7% ,which were significantly higher than that in group B（P〈0.05）. STB,SCB,TBA,ALT and AST were lower in group A than in group B（P〈0.05）. The increase of albumin after treatment was more significant in group A than in group B（P〈0.05）. Conclusion ：Glutathione has better efficacy than potassium magnesium aspartate in the treatment of patients with viral heoatitis.
出处
《临床医药实践》
2005年第11期816-818,共3页
Proceeding of Clinical Medicine
