摘要
幽门螺杆菌感染与胃癌流行有关。本研究利用微核试验，观察了幽门螺杆菌对人外周血淋已细胞、人胃粘膜上皮细胞微核形成率的影响。结果表明：２株幽门螺扦菌碎片的蛋白浓度在０．６－３．９μｇ／ｍｌ范围内均可使人外周血淋巴细胞及人胃粘膜细胞微核率增高２倍以上，存在剂效关系（Ｐ＜０．０５）；大肠杆菌对照则无此作用。为研究幽门螺杆菌感染与胃癌发生的关系提供了较直接的线索。
Infection of Helicobacter pylori(HP) was considered as a risk factor for stomachcancer. Study on the genetoxicity of HP would be useful to understarid HP’s role played incarcinogenesis. Micronucleus assay in human peripheral blood lymphocytes with HP extractwas conducted.Induction of micronucleus in cultured human lymphocytes and GES-1withextract of HP in dosage of 0.6-3. 9μg protein/ml was observed.However,E.coli did notshrMwsuch effect.Result indicated the clastogenecity of HP may account for the gastric car-Cinogenesis.
出处
《癌变·畸变·突变》
CAS
CSCD
1996年第3期154-156,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
幽门螺杆菌
微核
人淋巴细胞
胃癌
Helicobacter Pylori
Micronucleus
Cultured human lymphocyte
Human gastricepithelia cell(GES-1)
