摘要
为探讨血浆胰升血糖素对非胰岛素依赖型糖尿病（NIDDM）发病的影响,对327例糖耐量正常者、25例NIDDM患者和20例经药物治疗的NIDDM患者的空腹血糖、血清胰岛素和血浆胰升血糖素浓度进行研究。结果显示,NIDDM患者的血糖、胰升血糖素和胰岛素水平（分别为9.28±2.30 mmol/L,159.65±34.13ng/L和15.16±10.79mIU/L）均明显高于正常人（分别为4.71±0.64mmol/L,83.12±12.39ng/L和10.43±6.86mIU/L）;经治疗的NIDDM患者的血糖和胰升血糖素水平（分别为7.15±2.44mmol/L和124.99±37.23ng/L）均低于NIDDM患者,胰岛素水平无明显差别。相关分析表明,3组受试者的血糖与血浆胰升血糖素水平均呈极显著正相关（r分别为0.8720、0.9400和0.8731,P均<0.001）,而血糖与血清胰岛素水平无密切相关。提示胰升血糖素的升高可能是NIDDM主要的、始动性的发病因素。
In order to probe into the role of plasma glucagon in the pathogenesis of NIDDM, the concentrations of fasting blood glucose, serum insulin and plasma glucagon were assayed in 327 subjects with normal glucose tolerance (group Ⅰ), 25 patients with NIDDM (group Ⅱ) and 20 NIDDM patients treated with drugs (group Ⅲ). The levels of blood glucose, plasma glucagon and serum insulin in group Ⅱ were 9. 28±2.30 mmol/L,159. 55±34. 13ng/L and 15. 16±10. 79mIU/L respectively, and were significantly higher than those of group Ⅰ(4. 71±0. 64mmol/L,83.12±12.39ng/L and 10. 43±6. 86mIU/L respectively). The levels of blood glucose and plasma glucagon in group Ⅲ were 7. 15±2. 44 mmol/L and 124. 99±37. 23 ng/L respectively and were lower than those of group Ⅱ, no significant difference in serum insulin levels was noted. Correlation analysis showed that blood glucose had a positive linear correlation with plasma glucagon in the three groups (r=0. 8720,0. 9400,0. 8731,respectively, P< 0. 001 ), but no linear correlation between blood glucose and serum insulin was detected. It suggests that elevation of plasma glucagon possibly is a significant and primary factor in pathogenesis of NIDDM.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1996年第1期9-11,共3页
Chinese Journal of Endocrinology and Metabolism
