摘要
目的观察白术水煎剂外用对致炎小鼠血清肿瘤坏死因子(TNF-α)含量的影响。方法将ICR小鼠随机分3组:模型组、白术组、骨友灵组,分别以白术水煎剂、骨友灵搽剂、生理盐水涂抹小鼠右耳廓,再以二甲苯致炎。采集血清用L929细胞以结晶紫染色法测TNF-α含量。结果白术组小鼠血清TNF-α含量低于模型组,且有显著性差异(P<0.05)。结论白术水煎剂外用可降低致炎小鼠血清中TNF-α含量,可能其抗炎作用与降低TNF-α含量有关。
Objective To observe the effect of Baizhu Decoction used externally on the serum content of tumor necrosis factor-α （TNF-α） in mice with auricle infection. Method The ICR mice were randomly divided into the model group, Baizhu group and Guyouling group. Baizhu Decoction, Guyouling Liniment and normal saline solution were painted on mouse auricle followed by dimethylbenzene to induce auricle infection. The TNF-α content in mouse serum was detected by the method of cancer cell line L929 stained by crystal violet. Result The serum TNF-α content in Baizhu group was lower than that in the model group with a significant difference （ P 〈 0.05 ）. Conclusion Baizhu Decoction used externally can decrease the content of serum TNF-α in mice with auricle infection, so its anti-infection effect maybe related to that it can decrease the TNF-α content.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2005年第6期57-58,共2页
Journal of Beijing University of Traditional Chinese Medicine
基金
北京中医药大学大学生三级课题(No.YD2003-10)
关键词
白术
外用药
炎症
肿瘤坏死因子
小鼠
Baizhu Decoction
drugs used externally
infection
tumor necrosis factor
mice
