摘要
用放射免疫分析法和比浊法测定ＡＰＩ＿（０１３４）对大鼠血浆血栓素Ｂ＿２（ＴＸＢ＿２）浓度、血小板ＴＸＢ＿２生成血小板聚集的影响。静脉注射ＡＰＩ＿（０１３４）７０ｍｇ或１００ｍｇ·ｋｇ￣（－１）显著降低血浆ＴＸＢ＿２浓度，其降低率分别为３８．８％和５１．６％， ＡＰＩ＿（０１３４）明显抑制ＡＤＰ诱导的大鼠血小板聚集和ＴＸＢ＿２生成，抑制率分别为２７．８％、３９．５％和４１．４％、５３．６％，两抑制率间呈显著正相关。对胶原诱导的大鼠血小板聚集和ＴＸＢ＿２生成也有明显抑制作用，其抑制率分别为２４．３％、３５．０％和４４．８％、４５．５％，两抑制率间相关显著。
Platelet aggregation and thromboxane B_2(TXB_2)production induced by adenosine diphosphate(ADP)or coliagen(Coll),and plasma TXB_2 concentration were studiedon rats by turbidimetry and radioimmunoassay. API_(0134) 70 and 100mg/kg administed iv de-creased d rats plasma TXB_2 cmcentration,the decrements by API_(0134) were 38.8 % and 51.5%respectively. API_(0134) 70 and 100mg/kg injected iv inhibited platelet aggregation as well asthe production of TXB_2, The inhibition were dose-depended;27.8%～39.5%(ADP-induced)and 24.3～35.0%(Coll-induced ) for piatekt aggregation,41.4%～53.6(ADP-indueed)and44.8%～45.5%(Coll-induced)for the TXB_2 production. There was a positive correlation be-tween the inhibition of platelet aggregation and production of TXB_2 induced bv ADP orColl.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1996年第1期99-102,共4页
Chinese Journal of Pathophysiology
基金
湖北省自然科学基金
