摘要
目的研究趋化因子SDF-1及其受体CXCR4在皮肌炎皮损中的表达及其意义。方法采用免疫组化ABC法检测及图像分析观察22例皮肌炎皮损和15例正常对照皮肤石蜡切片中SDF-1和CXCR4的表达。结果SDF-1和CXCR4在皮肌炎皮损中的表皮基底层、棘层、颗粒层及腺体、血管平滑肌中均有较强表达,而在正常皮肤中表达下降,两者有显著性差异(均P<0.05)。结论SDF-1和CXCR4可能与皮肌炎的发生和发展相关,SDF-1和CXCR4为皮肌炎的免疫治疗提供了新的靶分子。
Objective To study the expressions of stromal cell derived factor-1 and its receptor CXCR4 in dermatomyositis and their role in occurrence and development of dermatomyositis. Methods The expressions of SDF-1 and CXCR4 was detected in the skin lesion of 22 patients with dermatomvositis and 15 normal controls by immunohistochemical technique（ABC） and image analyse. Results The expressions of SDF-1 and CXCR4 in the epidermal basal cell layer,stratum spionsum,granular layer,and dermal gland and the smooth muscle of the blood vessel of dermatomyositis lesion were significantly stronger,but low expressions were found in normal control. The expressions had significant difference between dermatomyositis and normal control（ both P 〈 0.05 ）. Conclusion Chemokine SDF-1 and its receptor CXCR4 might play an important role in the pathogenesis of dermatomyositis. These proteins provide new targets for immune therapy.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2005年第11期654-657,共4页
The Chinese Journal of Dermatovenereology
