摘要
目的:探讨肿瘤坏死因子A-308(turmor necrosis factor A-308,TNFA-308)基因多态性与维吾尔族慢性牙周炎(chron ic periodontitis,CP)易感性的关系。方法:收集维吾尔族重度CP 4 l例、中度CP 43例、轻度CP 49例和同族健康对照92例个体的颊黏膜拭子,提取DNA,采用序列特异引物多聚酶链反应(sequence spec ific prim ers-polym erase chain reaction,SSP-PCR)法测定TNFA-308位点的基因型,比较各基因型检出率的差别。结果:TNFA-308位点基因型分布在重度CP、中度CP、轻度CP与健康组之间无差异。结论:TNFA-308位点基因型可能与维吾尔族CP遗传易感性无相关性。
AIM ：To investigate the tumour necrosis factor A -308 （TNFA -308 ） genotype and its association with the susceptibility of chronic periodontitis in Uighur patients. METHODS：Genomic DNA was obtained from buccal swabs of 41 subjects with severe chronic periodontitis,43 subjects with moderate chronic periodontitis,49 subjects with mild chronic periodontitis and 92 ethnically matched healthy control individuals. Genotypes of TNFA - 308 was analyzed by SSP - PCR method. Then compared the differences in distribution of each genotype. RESULTS ： No statistical differences in distribution of TNFA -308 genotype was observed among the groups with severe chronic periodontitis, moderate chronic periodontitis, mild chronic periodontitis and healthy control individuals （ P 〉 0.05 ）. CONCLUSION：This study suggests that the TNFA -308 genotype is not the indicator for the susceptibility of chronic periodontitis in Uighur patients.
出处
《牙体牙髓牙周病学杂志》
CAS
2005年第10期550-552,共3页
Chinese Journal of Conservative Dentistry
基金
新疆维吾尔自治区自然科学基金资助项目(200321105)
新疆维吾尔自治区重点实验室开放课题资助项目(XJDX0208-2003-04)
