摘要
目的初步探讨盐酸纳洛酮在治疗弥漫性轴索损伤中的量效关系及其机理。方法将60例弥漫性轴索损伤病人随机分为对照组、纳洛酮治疗组1和纳洛酮治疗组2,对照组采用止血、护脑、改善微循环、降颅压等常规治疗,治疗组在常规治疗的基础上,分别以不同剂量或方法增加盐酸纳洛酮治疗,观察患者格拉斯哥昏迷评分(GCS)的变化、神智转清率和远期疗效。结果盐酸纳洛酮治疗组格拉斯哥昏迷评分从第5d起明显高于对照组(P<0.05),神智转清率和格拉斯哥预后评分(GOS)也明显优于对照组。纳洛酮治疗组2的疗效较纳洛酮治疗组1更为理想,有显著性差异(P<0.05)。结论应用盐酸纳洛酮可有效改善弥漫性轴索损伤患者的意识状况,缩短昏迷时间。早期、大剂量、静脉注射是应用盐酸纳洛酮治疗的关键。
Objective To study the dose - effect relationship of naloxone in treatment of diffuse axonal injury and its mechanism. Methods Sity patients of diffuse axonal injury were randomly assigned into three groups. The control group was treated with routine measures and the other groups were treated with different doses of intravenous naloxone. Glasgow coma scale （GCS）, consciousness recovery rate and GOS were compared. Result From the 5th day GOS of treatment groups was better .than that of the control （P〈 0.05 ）, the prognosis of treament groups was better than that of the control after ,3 months follow up. Naloxone injected group 2 was more effective than that of the Naloxone injected group 1 （ P〈 0.05）. Conclusion Naloxone can improve the recovery of coma in patients with diffuse axonal injury. The key of naloxone therapy is early large dose naloxone intravenous injection.
出处
《实用预防医学》
CAS
2005年第3期512-514,共3页
Practical Preventive Medicine
