摘要
从１９８９年至１９９１年对大庸市一个精神发育迟滞高发村进行了病因学研究；通过流行病学调查、智力测定、家系调查、细胞遗传学及生化检查和环境检测等分析，发现其主要致病原因系缺碘所致克汀病。证实湖南为缺碘省份，并提出初步治理方案。
rom l989 to l991,etiological study had been performed on a village with high incidence ofmental retardation(MR)in Dayorig city.By means of epidemiological investigation, measure-ment of intellectual quality,pedigree analysis,cytogenic and biochemical analyses and environ-mentaI monitoring,477 individuals had been studied and l29 MR patients were found.Theprevalence rate was 27.04%,Chromosomal exam showed no abnormality among MR patients.Metabolic-enzyme difficiencies,such as phenylketone,mucopolysachride,antioxidase, etc,hadbeen exchded by biochemical enzymatic measures. Contents of various trace elements in environ-ment were normal except concentration of iodine in water,which was only 0.8～1.7μg·L-1.Theresults suggest that mental retardation in this village is mainly caused by iodine deficiency cre-tinism and Hunan is one of the iodine deficienct provinces,Preliminary improvement project hasalso been recommended.
出处
《湖南医科大学学报》
CSCD
1996年第1期25-30,共6页
Bulletin of Hunan Medical University
关键词
智力迟钝
病因学
细胞遗传学
碘缺乏
流行病学
mental retardation
intelligence tests
pedigree
cytogenics
chemistryanalysis
epidemiology
enviromental monitoring
