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Myostatin基因研究进展 被引量：1

Research Progress of Myostatin
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摘要 肌肉生长抑制素基因(M yostatin,M STN)是1997年发现的骨骼肌生长发育负调控因子,属于TGF-β家族。研究证实人的M yostatin基因由3个外显子和2个内含子组成,在骨骼肌中特异性表达。目前,该基因已分别在人、牛和猪的染色体上定位。M yostatin是肌肉生长的负性调控因子,通过抑制成肌细胞的增殖而发挥作用。M yostatin突变或缺失均可异致肌肉质量的显著增加。文章主要阐述了肌肉生长抑制素基因的结构,功能,及其定位,并对其在畜牧业及医学上的应用前景作了综合论述。 Myostatin,a new member of the TGF-β superfamily,mas found in 1997. It is specifically expressed in skeletal muscle cells. The genomie structure of human myostatin gene contains 3 exons and 2 intron. Myostatin is a negative regulator of skeletal muscle mass. The skeletal muscle of mutant animals with null or low-activity myostatin would show significantly larger diameter of more quantity of fiber,which was termed as double muscling. Myostatin is mapped to 2q33.2 in human, 2qll in cattle and 15q2.3 in pig.
作者 戴晔 候水生 刘小林
机构地区 西北农林科技大学动物科技学院 中国农业科学院畜牧研究所
出处 《畜牧兽医杂志》 2005年第6期12-14,共3页 Journal of Animal Science and Veterinary Medicine
关键词 肌肉生长抑制素 骨骼肌 双肌 myostatin skeletal muscle double muscle
分类号 S811.3 [农业科学—畜牧学]
  • 相关文献

参考文献18

  • 1McPherron A C.Regulation of skeletal muscle mass in mice by a new TGF-β super family member[J].Nature,1997,387:86-90.
  • 2Cheifetz S,The transforming growth factor-β system,a complex pattern of cross-reactive ligands and receptors[J].Cell,1987,48:409-415.
  • 3Gonzalez-Cadavid N F,Taylor W E,Yarasheski K et al.Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.Proc Natl Acad Sci USA,1998;95(25):14938-14941.
  • 4欧阳红生,孙燕,张永亮,李慎涛,张锐,廖晓萍,张玉静,赵建军,赵凤云.猪肌生成抑制素基因的克隆和序列测定[J].中国兽医学报,2001,21(5):479-481. 被引量：23
  • 5McPherron A C,Lee S J.Double muscling in cattle due to mutations in the myostatin gene[J].Proc Natl Acad Sci USA,1997,94(23):12457-12461.
  • 6马现永,施振旦,曹永长,毕英佐,马静云.鸡、鹅肌肉生成抑制因子基因的克隆及序列分析[J].华南农业大学学报,2004,25(2):85-88. 被引量：14
  • 7Sonstegard T S.Refinement of bovine chromosome 2 linkage map near the mh locus reveals rearrangements between the bovine and human genome[J].Animal Genetics,1998a,29(5):341-347.
  • 8Smith T P.Myostatin maps to the interval containing the bovine mh locus[J].Mammalian Genome,1997,8(10):742-744.
  • 9杨威,王琨,陈岩,张勇,黄波,朱大海.重组肌肉抑制素功能分析及其对鸡肌肉发育的抑制作用[J].生物化学与生物物理学报,2003,35(11):1016-1022. 被引量：9
  • 10Sharma M,Kambadur R,Matthews KG et al.Myostatin,a transforming growth factor-beta superfamily member,is expressed in heart muscle and is up regulated in cardiomyocytes after infarct[J].Cell Physiol,1999,180:1-9.

二级参考文献25

  • 1Mc Pherron A C，Molecular Biology Genetics，1997年
  • 2Mc Pherron A C，Proc Nat Acad Sci USA，1997年，94卷，23期，12457页
  • 3LIN J, ARNOLD H B, DELLA-FERA M A, et al. Myostatin knockout in mice increases myogenesis and decreases adipogenesis [J]. Biochem Biophys Res Commu, 2002, 291(3): 701-706.
  • 4CASAS E, KEELE J W, FAHRENKRUG S C, et al. Quantitative analysis of birth, weaning, and yearling weights and calving difficulty in Piedmontese crossbreds segregating an inactive myostatin allele [J]. J Anim Sci, 1999, 77(7): 1 686-1 692.
  • 5GROBET L, MARTIN L J R, PONCELET D, et al. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle[J]. Nat Genet,1997, 17:71-74.
  • 6KAMBADUR R, SHARMA M, SMITH T P, et al. Mutations in myostatin in double-muscled Belgian Blue and Piledmontese cattle [J]. Genome Res, 1997, 7(9), 910-916.
  • 7McPHERRON A C, LEE S J. Double muscling in cattle due to mutations in the myostatin gene [J]. Proc Natl Acad Sci, 1997,94:12 457-12 461.
  • 8SHARMA M, KAMBADUR R, MATTHEWS K G, et al. Myostatin, a transforming growth factor-[beta] superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct[J]. J Cell Physiol, 1999; 180:1-9.
  • 9McPHERRON A C, LEE S J. Suppression of body fat accumulation in myostatin-deficient mice [J]. J Clin Invest, 2002,109(5): 595-601.
  • 10MCPHERRON A C, LAWLER A M, LEE S J. Regulation of skeletal muscle mass by a new TGF-β superfamily member[J]. Nature, 1997, 387(6 628), 83-90.

共引文献52

同被引文献17

  • 1曹少先,张文伟,茆达干,管峰,杨利国.生长抑素基因疫苗质粒pcS/2SS的构建、表达及免疫[J].农业生物技术学报,2005,13(4):477-481. 被引量：22
  • 2Se-Jin Lee.REGULATION OF MUSCLE MASS BY MYOSTATIN[J]. Annual Review of Cell and Developmental Biology . 2004
  • 3Se-Jin Lee,Alexandra C McPherron.Myostatin and the control of skeletal muscle mass[J]. Current Opinion in Genetics & Development . 1999 (5)
  • 4Luc Grobet,Dominique Poncelet,Luis José Royo,Benoit Brouwers,Dimitri Pirottin,Charles Michaux,Fran?ois Ménissier,Marta Zanotti,Susana Dunner,Michel Georges.Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle[J]. Mammalian Genome . 1998 (3)
  • 5F Delpeyroux,N Chenciner,A Lim,Y Malpiece,B Blondel,R Crainic,S van der Werf,RE Stree.A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles. Science . 1986
  • 6Braun R,Babiuk L A,van Drunen Littel-van den Hurk.Compatibility of plasmids expressing different antigens in a single DNA vaccine formulation. The Journal of general virology . 1999
  • 7JA Wolff,RW Malone,P Williams,W Chong,G Acsadi,A Jani,PL Felgn.Direct gene transfer into mouse muscle in vivo. Science . 1990
  • 8McPherron A C,Lee S J.Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences of the United States of America . 1997
  • 9Feldman Brian J,Streeper Ryan S,Farese Robert V,Yamamoto Keith R.Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings of the National Academy of Sciences of the United States of America . 2006
  • 10McpHerron A C,Law ler A M,Lee S J,et al.Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature . 1997

引证文献1

二级引证文献2

畜牧兽医杂志
2005年 第6期

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