摘要
为探讨胶质肉瘤的临床病理特征、组织发生学及预后，观察了12例胶质肉瘤，其肿瘤均发生于大脑半球，颞叶多见。肿瘤半数界限清楚，质硬。随访10例，9例死亡，平均生存8个月，1例生存3年2个月。部分病例HE染色切片中难以确定梭形肿瘤细胞来源。通过电镜及胶质纤维酸性蛋白、Mac387、波形蛋白、第Ⅷ因子相关抗原免疫组织化学染色观察，证实肿瘤中均含胶质母细胞瘤和恶性纤维组织细胞瘤成分，仅1例尚含骨肉瘤成分。其组织起源为原始多潜能间叶细胞。
In order to study the clinicopathological features, histogenesis and prognosis, 12 cases of gliosarcorna were reported representing 0. 4 % of a series of 2743 patients undergoing biopsy for CNS tumors. All the tumors originated from the cerebral hemispheres with a predilection for the ternporal lobes. HaIf of the cases show rnore firm consistency and are rather well demarcated from brain tissue. Clinically, they are sornetimes mistaken for meningiomas. Of the 10 patients with follow-up, 9 have died. The mean survival period after operat1on was 8 rnonths, l cases is still alive and well for 3. 2 years. There were some cases in which the origin of spindle cell populations collld not be determined by H & E staining. Glioblastoma and malignant fibrous histiocytoma (MFH ) element of the tumor was confirmed by electron microscopical examination and irnrnunohistochemical stains for GFAP, Mac 387,VIM, FV Ⅲ RA, etc. Osteosarcoma cornponent in the turnor was detected in one case. It was accepted that MFH arose from the primitive uncommited mesenchyrne.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第3期129-131,共3页
Chinese Journal of Pathology
关键词
脑肿瘤
肉瘤
免疫组织化学
病理
Brain neoplasms
Sarcoma
Immunohistochemistry
