摘要
脊髓损伤的治疗一直是医学界的难题。脊髓损伤后神经元无法依靠自身再生修复,轴突再生困难,同时神经胶质瘢痕阻碍再生轴突的通过,因此脊髓损伤后减少神经细胞坏死,促进轴突再生,减少胶质瘢痕的形成是临床治疗的关键。许多研究发现嗅鞘细胞是神经系统中具有促进神经轴突再生,引导轴突正确生长的独特细胞,为脊髓损伤的修复带来了希望,但临床结果很不理想,为了提高其修复神经和正确引导轴突生长的能力,目前许多研究将基因工程技术和组织工程技术应用于其种植过程中,取得了一定的成果。
The treatment of spinal cord injury is always a stubborn problem for neurosurgeons because nerve cell cannot regenerate by itself and the glia scar can prevent the axonal regeneration. Therefore, to decrease the neuron death and formation of scar and to increase axonal regeneration are the keys for clinical treatment. Many studies showed that the olfactory ensheathing cells（OEC） can promote axonal regeneration and prover axonal growth, bringing hope for treament of spine injury, but the result is not satisfactory in clinic. In order to improve the clinical effect of OES transplantation many studies combine it with genetic engineering and tissue engineering and some progress is made.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2005年第10期1181-1183,共3页
Academic Journal of Second Military Medical University
基金
国家自然基金重点项目(30330700)
关键词
嗅鞘细胞
细胞移植
脊髓损伤
olfactory ensheathing cell
cell transplantation
spinal cord injuries
