摘要
目的评价立体定向放射治疗结合化学治疗原发性颅内淋巴瘤(primary intracranial lymphoma,PIL)的临床疗效.方法分析1997～2002年42例经过病理证实的PIL,均给予立体定向放射治疗,再给予全脑外照射20～30Gy,最后接受以甲氨蝶呤(MTX)大剂量化疗为基础的联合化疗4～6疗程.结果随访9～42个月,卡氏评分平均提高20分,即期疗效完全缓解39例,部分缓解3例,无肿瘤增大者.42例患者死亡31例,存活11例;平均生存期28.4±4.1个月;1、2、3年局部控制率为92.9%,73.8%和52.3%;1、2、3年生存率分别为85.7%,76.2%和57.1%;无明显毒副作用.结论立体定向放射治疗结合以大剂量MTX化学治疗是治疗PIL的有效,安全的方法.
Objective To evaluate the clinical efficacy for the patients with primary intracranial system lymphoma（PIL） treated by stereotactic radiotherapy combined with MTX based chemotherapy. Methods From 1997 to 2002, fourty-two cases of PIL patient confirmed by pathological examination were given stereotactic radiotherapy followed by external whole brain radiotherapy and high dose MTX plus VCR, PCB,DXM. Results The results showed that complete response in thirty-nine patients and partial response in three patients and the response rate is 100 %. 31 patients died and 11 patients survived at the end of the following-up and the mean survival is 28.4 ± 4.1 months. 1,2,3 year local control rate is 92.9 %, 73.8 % and 52.3 % ; and 1-, 2-, 3-year survival rate are 85.7 %, 76.2 % and 57.1% respectively. And there is no significant side effects. Conclusion Stereotactic radiotherapy combined with high dose MTX based chemotherapy is a safe and effective multimodality treatment for PIL.
出处
《立体定向和功能性神经外科杂志》
2005年第5期290-293,共4页
Chinese Journal of Stereotactic and Functional Neurosurgery
基金
卫生部科研基金项目(编号:WKJ-005-3-006)
关键词
淋巴瘤
颅内
立体定向放射治疗
化学治疗
Lymphoma
Intracranial
Stereotactic radiotherapy
Chemotherapy
