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脂肽类抗真菌新药及其结构改造 被引量：2

Lipopeptid Antifungals and Their Structural Modifications
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摘要 新型脂肽类抗真菌药物棘白菌素类似物是-β1,3-D-葡聚糖合成酶的非竞争性抑制剂,主要作用于念珠菌属和曲霉菌属,不良反应较少,具有临床应用前景。通过对该类化合物有关结构改造研究及上市产品的介绍,提供药物研发的一种视角和思路。 Eehinoeandin derivatives are the novel lipopeptid antifungals that inhibit β-1, 3-D-gluean synthase. They possess strong action against some fungals such as Candidas, Aspergillus etc. and rare side effect, so they are potential antifungals. In the review, some new ideas for drag R ＆ D would be provided by introduction of the marketed products and the structural modifications.
作者 马丽 贺宝元 周伟澄
机构地区 上海医药工业研究院
出处 《药学进展》 CAS 2005年第10期440-448,共9页 Progress in Pharmaceutical Sciences
基金 上海市科学技术委员会资助项目(04JC14068 04DZ05902)
关键词 β-1 3-D-葡聚糖合成酶抑制剂 棘白菌素 抗真菌 结构改造 Inhibitor of β-1, 3-D-gluean synthase Eehinocandins Antifungin Structural modification
分类号 R914 [医药卫生—药物化学]
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参考文献23

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二级参考文献23

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共引文献11

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二级引证文献9

药学进展
2005年 第10期

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