摘要
本文对薄荷脑促进氯霉素的经皮渗透作用作了初步观察，２％薄荷脑在氯霉素醇溶液或在４：３：３溶液中，对１％氯霉素均有显著的促进经皮渗透作用，该作用在４ｈ即有显著性差异，随时间增加透皮量也进一步增加。研究表明２％月桂氮酮（氮酮）在上述两种溶剂中也有明显的促进氯霉素的经皮渗透作用，且随时间增加而增加。１％月桂氮酮和ｌ％薄荷脑同时应用，比两者在２％浓度单独应用时的助渗作用更强。
he effect of menthol on the skin permeation of chloramphenicol was investigated using mice skin in vitro. The.chloramphenicol was studied in different solvents containing 95% alcohol and 4:3:3 solvent mixture (alcohol:] .2-propanediol:water). 2%. menthol showed a rapid (after 4h ,P<0.01 ) and strong enhancement of penetration of1% chloramphenicol in both solvents, the penetration became higher as time went on, as did 2% azone. The use ofa combination of 1 % menthol with 1% azone showed greater penetration enhsncement than the sum of those with2% menthol alone and 2% azone alone.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第5期217-218,共2页
Chinese Journal of Hospital Pharmacy
