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突触前受体的药理学研究进展

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摘要 综述了突触前受体存在的证据、分类、调节和临床意义。突触前受体按不同的分类方法可分为突触前自调受体和旁调受体;抑制性和易化性突触前受体;G-蛋白偶联型和离子通道型突触前受体。突触前受体调节递质释放的机制,可能与钙通道、钾通道及囊泡释放复合物的调节有关。通过研制合适的突触前受体的激动剂或拮抗剂,适度调节神经末梢递质的释放,可达到控制或治疗多种疾病(如高血压、精神疾患、阿尔茨海默病、心肌缺血等)的目的。
作者 师晨霞 任雷鸣
机构地区 河北医科大学基础医学院 河北医科大学药学院
出处 《华西药学杂志》 CAS CSCD 北大核心 2005年第5期423-426,共4页 West China Journal of Pharmaceutical Sciences
关键词 突触前受体 自调受体 旁调受体 突触前调节 钙通道 钾通道
分类号 R962 [医药卫生—药理学]
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参考文献19

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华西药学杂志
2005年 第5期

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