摘要
流行病学资料表明,AFB_1、HHBV感染及饮用污染水,有协同致肝癌作用。虽然已有人对感染了土拨鼠肝炎病毒(WHV)的土拨鼠进行长期观察,证实WHV感染与土拨鼠肝癌的发生有密切关系,但尚未见用酶组织化学方法对AFB_1及HBV在肝细胞癌前病变过程中作用的研究报道。本研究用能感染HHBV的最低等的灵长类树鼩进行实验,用酶组织化学方法,以被普遍认为是肝细胞癌前病变的γ-谷氨酰转肽酶阳性肝细胞增生灶(γ-GT灶)为观察指标,研究HHBV感染在AFB_1致树鼩肝癌过程中的生物学作用。
When Tupaia belangeri was infected with human hepatitis B virus (HHBV), thehepatocytes showed up with precancerous change. If aflatoxin B1 (AFB1) was admini-stered simultaneously, a coordinated effect of HHBV and AFB1 on precancerous pro-liferation of hepatocytes was obviously seen. Thus, an experimental pathologicalevidence for the careinogenic effect of HBV is indicated.
出处
《肿瘤》
CAS
CSCD
北大核心
1989年第6期241-243,共3页
Tumor
