期刊文献+

N,N-二甲基甘氨酸酯的催化合成 被引量:1

Catalyzed synthesis of N,N-dimethyl glycine esters
在线阅读 下载PDF
导出
摘要 在SnCl2的催化作用下,N,N-二甲基甘氨酸与脂肪醇反应合成了10个N,N-二甲基甘氨酸酯,产率为89.8%~98.0%. Ten N, N-dimethyl glyeine esters were synthesized in yields of 89.8% -98.0% from N, N-dimethyl glyeine and fatty alcohols with SnCl2 as catalyst.
出处 《化学试剂》 CAS CSCD 北大核心 2005年第9期565-567,共3页 Chemical Reagents
关键词 N N-二甲基甘氨酸酯 催化 合成 N, N-dimethyl glycine ester catalysis synthesis
  • 相关文献

参考文献8

  • 1Fleeker C,Wong O,Rytting J H.Facilitated transport of basic and acidic drugs in solution through snake skin by a new enhancer-dodecyl N,N-dimethamino acetate[J].Pharm.Res.,1989,6(6):443-448.
  • 2Wong O,Hungting J,Nishihata T,et al.New alkyl N,N-dialkyl-substituted amino acetates as transdermal penetration enhancers[J].Pharm.Res.,1989,6(4):286-295.
  • 3Hirvonen J,Rytting J H,Paronen P,et al.Dodecyl N,N-dimethylamino acetate and azone enhance drug penetration across human,snake,and rabbit skin[J].Pharm.Res.,1991,8(7):933-937.
  • 4李伟杰,汪波,许遵乐.N,N-二甲基氨基乙酸酯的合成及其应用研究[J].中山大学学报(自然科学版),2003,42(6):44-46. 被引量:7
  • 5牛梅菊.固体氯化物催化合成醋酸脂肪酸酯[J].化学试剂,1994,16(2):127-128. 被引量:10
  • 6任玉荣,贾树勇,于庆勇,侴晓玉.氯化亚锡催化合成乙酸丁酯的研究[J].吉林师范大学学报(自然科学版),2004,25(2):87-88. 被引量:8
  • 7Zerda J D,Barak G,Sasson Y.Selective monoetherification and monoesterification of diols and diacids under phase-transfer conditions[J].Tetrahedron,1989,45(5):1533-1536.
  • 8Clarke H T,Weisshaus G S S Z.The action of formaldehyde on amines and amino acids[J].J.Am.Chem.Soc.,1933,55(11):4571-4587.

二级参考文献9

共引文献22

同被引文献20

  • 1BUYUKTIMKIN S, BUYUKTIMKIN N, RYTTING J H. Interaction of indomethacin with a new penetration enhan- cer,dodecyl 2-(N,N-dimethylamino) propionate(DDAIP) : its effect on transdermal delivery [ J ]. Int. J. Pharm., 1996,127(2) :245-253.
  • 2. BUYUKTIMKIN S, BUYUKTIMKIN N, RYTTING J H. Synthesis and enhancing effect of 2-( N, N-dimethylami- no) propionate on the transepidermal delivery of indom- ethacin, clonidine and hydrocortisone [ J ]. Pharm. Res. , 1993,10(11) :1 632-1 637.
  • 3TURUNEN T M, BUYUKTIMKIN S, BUYUKTIMKIN N, et al. Enhanced delivery of 5-fluorouracil through shed snake skin by two new transdermal penetration enhancers [ J]. Int. J. Pharm., 1993,92(1/3) :89-95.
  • 4TURUNEN T M,URTTI A,PARONEN P,et al. Effect of some penetration enhancers on epithelial membrane lipid domains:evidence from fluorescence spectroscopy studies [ J ]. Pharm. Res. , 1994,11 ( 2 ) :288-294.
  • 5FINNIN B C, MORGAN T M. Transdermal penetration enhancers : applications, limitations, and potential [ J ]. J. Pharm. Sci. , 1999,88 (10) :955-958.
  • 6WOLKA A M,RYTTING J H,REED B L,et al. The in- teraction of the penetration enhancer DDAIP with a phos- pholipid model membrane [ J ]. Int. J. Pharm. , 2004,271 (1/2) :5-10.
  • 7NOVOTNY J, KOVARfKOVA P, NOVOTNY M, et al. Dimethylamino acid esters as biodegradable and reversi- ble transdermal permeation enhancers:effects of linking chain length, chirality and polyfluorination [ J ]. Pharm. Res. ,2009,26(4) :811-821.
  • 8HU L,SILVA S M C,DAMAJ B B,et al. Transdermal and transbuccal drug delivery system:enhancement using ion tophoretie and chemical approaches [ J ]. Int. J. Pharm. , 2011,421 ( 1 ) : 53-62.
  • 9MEIER-DAVIS S R, DEBAR S, MARTIN R, et al. En- hancing the skin flux of tolnaftate utilizing the novel ex- cipient, dodeeyl-2 -N , N-dimethylaminopropionate (DDAIP) [ J ]. J. Pharm. Drug Deliv. Res. , 2012,1 ( 1 ) : 1-3.
  • 10BUYUKTIMKIN S, BUYUKTIMKIN N. Method for the manufacture of dodeeyl 2- ( N, N-dimethylamino ) -propi- onate:EP,1 428 816B1 [ P]. 2012-05-09.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部