摘要
通过主胰管逆行注入不同剂量的胆汁和胰蛋白酶混合液，在２２只猫诱发了程度不同的急性胰腺炎。组织病理学表明：Ａ组动物主胰管注入０．８ｍｌ／ｋｇ混合液，诱发的胰腺炎较轻，病理改变以间质水肿为主；Ｂ组动物注射１．０ｍｌ／ｋｇ混合液，胰腺病变为广泛坏死；Ｃ组动物注射１．２ｍｌ／ｋｇ混合液，胰腺广泛坏死合并肺、肝损害。所有实验动物腹腔液淀粉酶均明显升高，升高幅度与胰腺病变程度呈正比，与实验动物的生存时间呈反比。Ａ组动物腹腔液淀粉酶为４８９０Ｕ／Ｌ，其生存时间在７ｄ以上；胰腺坏死严重的Ｂ组动物，腹腔液淀粉酶为１３９５２Ｕ／Ｌ，生存时间５０．４ｈ；Ｃ组动物腹腔液淀粉酶２３８１０Ｕ／Ｌ，生存时间１０．４ｈ。实验结果表明：腹腔液淀粉酶测定对估价急性胰腺炎病变程度及预后有显著意义，可做为评定急性胰腺炎病变程度及估价预后的重要指标。
Acute pancreatitis(AP)was induced on 22 cats,by injecting the mixture of bile and trypsin at different doses into the main pancreatic duct(MPD).In Group A,7 cats revealed pancreatic interstitial edema after the injection of the mixture at 0.8mg/kg.In Group B,8 cats received the injection of the MPD at 1.0mg/kg which resulted in significant extensive necrosis of the pancreas.The same pathological change was found in Group C(7cats),combined with lesions of the lung and the liver.The survival time was different,more than 7 days in Group A,50.4 hours in Group B and 10.4 hours in Group C(P<0.001>.Amylase concentration also showed marked difference in different groups,4 890 U/Lin Group A;13 952 U/L in Group B and 23 810 U/L(P<0.001>in Group C.These results are directly proportional to the severity of AP,but inversely proportional to the survival time.It suggests that amylase concentration in abdominal fluid can be used as an important marker to evaluate the severity of AP and its prognosis.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1996年第3期195-198,共4页
Acta Academiae Medicinae Sinicae
