摘要
目的观察α-受体阻滞剂(络斯宝)对大鼠球囊功能老化的保护作用。方法健康Wistar雄性大鼠16只,分为:组1为正常对照组(n=5);组2为老化组(n=5);组3为老化+络斯宝组(n=6)。老化模型采用D-半乳糖催老,剂量为120mgkg,每日一次,腹腔注射,共计给药3个月;络斯宝的剂量为300ugkg,每日2次喂服。造模完成后,记录颈髓硬膜表面短声诱发电位。结果组1大鼠电位正常引出;组2老化大鼠在105dBSPL水平均未引出脊髓膜表面短声诱发电位;组3有3只在105dBSPL水平正常引出电位,3只未引出电位。结论α-受体阻滞剂(络斯宝)对球囊老化有一定的保护作用。
Objective To observe the protective effect of α - receptor antagonist （vasobral） against aging process in rats. Methods 16 healthy Wistar rats were divided into 3 groups： groupl as normal control（ n = 5）, group 2 as aging（ n = 5） and group 3 as aging pins vasobral（ n = 6）. The aging model was made by feeding the rats with D - galactose, 120 mg/kg, 1/d IP for 3 months. The dosage of vasobral was 300 ug/kg, 2/d PO, as the same duration with that of the D - galactose. Results The potentials recorded in group 1 was normal. There was no potentials recorded in group 2 at the level of 105 dB SPL. Among 6 rats in aging pins vasobral group, 3 rats had potentials elicited and 3 rats had no potentials recorded. Conclusion α - receptor antagonist vasobral has some protective effect on the function of the saccule.
出处
《听力学及言语疾病杂志》
CAS
CSCD
2005年第5期344-346,351,共4页
Journal of Audiology and Speech Pathology
基金
全军医药卫生科研基金课题(编号01L047)
关键词
Α受体阻滞剂
球囊
颈髓硬膜
短声诱发电位
α - receptor antagonist
Saccule
Cervical dura mater
Click- evoked potentials
