摘要
目的 应用扫描电镜观察老化大鼠及α 受体阻滞剂 (络斯宝 )处理后耳石的变化。方法 Wistar雄性大鼠 15只分为正常对照组 (n =5 )、老化组 (n =5 )、老化 +洛斯宝组 (n =5 )。老化造模完成后 ,分别进行扫描电镜观察。结果 正常大鼠的耳石形态正常 ;老化大鼠耳内可见线团样耳石融合、变平 ,有巨大耳石出现 ,可见球形和异形耳石 ,在移行细胞区 ,可见较多的耳石吞噬现象 ,球囊斑见小片状纤毛缺失 ;洛斯宝处理组可见球形耳石 ,有粘结现象 ,但一般均为光滑形态或绒线团外观 ,未见巨型耳石 ,移行区耳石数量较老化组少。结论 老化大鼠耳石出现明显异常 ,α 受体阻滞剂 (洛斯宝 )
Objective To observe the protective effect of α receptor antagonist(Vasobral) against the aging process in rats otoconia morphology.Methods 15 healthy Wistar rats were subdivided into 3 groups:Normal control( n=5 ),aging group( n=5 ) and aging plus Vasobral group( n=5 ).Results The aged otlith took the form of clew-like fusion,flattening and some giant otoconia.And there was also some sphericand strange otoconia.In the region of transitional cells,there was many otoconia phagocytosis.Some scraps of saccule lost cilia,And the otoconia in the Vasobral group appeared to be spheric and some of them adhered together,but this phenomenon was not wide-spread.No giant otoconia was found in this group.The otoconia in the transitional region was less compared with the aged group.Conclusion α receptor antagonist(Vasobral) has the effect of protection on the aging process of the otoconia.
出处
《听力学及言语疾病杂志》
CAS
CSCD
2004年第6期402-403,i001,共3页
Journal of Audiology and Speech Pathology
基金
全军医药卫生科研基金课题 (编号 0 1L0 47)
