摘要
目的:分析子宫内膜异位症的临床病理特点及探讨子宫内膜异位症的病因及发病机制.方法:根据病变部位的不同,将子宫内膜异位症分为:(1)内在性子宫内膜异位症;(2)外在性子宫内膜异位症;(3)混合性子宫内膜异位症.应用免疫组织化学S-P法,对112例子宫内膜异位症在位及异位内膜组织进行雌、孕激素受体的测定.结果:子宫内膜异位症的临床特点为慢性盆腔疼痛、痛经和不孕;连续切片证实内在性子宫内膜异位症来源于内膜基底层的腺体和间质.雌激素受体(ER)在在位及异位内膜组织中的阳性率分别为89%(39/44)和80%(45/56);孕激素受体(PR)在在位和异位内膜的阳性率分别为77%(34/44)和86%(48/56);两者均无统计学差异(P>0.05).结论:子宫内膜异位症是由多种原因引起的一种良性病变,但也具有种植、转移等肿瘤组织的特点.内在性子宫内膜异位症来源于内膜基底层的腺体和间质.ER、PR在异位症的在位及异位内膜组织中均有较高的阳性表达,表明其直接或间接地参与了子宫内膜异位症的发病过程,对其发生和发展起重要作用.
Objective： To investigate the cause, pathogenesis and the clinical-pathologic char-acteristics ofendometriosis. Method： According to the area of lesion endometriosis is divided into （1） adenomyosis （also named interna endometriosis, IEM ）; （2） extema endometriosis （EEM）; （3） mixed endometriosis. Estrogen and progestogen receptors are detected in eutopic and ectopic endometrium of 112 cases ofendometriosis using immunohistochemical S-P method. Results： The clinical characteristics ofendometriosis are chronic pelvic pain, dysmenorrhea and infertility. Serial section has confirmed that the histogenesis of the IEM is the direct infiltration of basal endometrium into the myometrial wall. The positive rate of ER in eutopic and ectopic endometrium is 89% （39/44） and 80% （45/56） respectively： the positive rate of PR in eutopic and ectopic endometrium is 77% （34/44） 和 86% （48/56） respectively. The positive rate of ectopic endometrium is higher than that in the eutopic endometrium but no statistical difference （P 〉 0.05）. Conclusion： Endometriosis is caused by multiple factors, which possesses some neoplastic features such as invasion and metastasis etc. although it is a benign disorder. Both ER and PR are highly expressed in eutopic and ectopic endometrium, which lead directly or indirectly to the pathogenesis ofendometriosis and promote the initiation and development of endometriosis.
出处
《江汉大学学报（自然科学版）》
2005年第3期86-89,共4页
Journal of Jianghan University：Natural Science Edition
