摘要
目的了解正常孕妇和妊娠期肝内胆汁淤积症(ICP)患者血清总胆汁酸水平。方法检测ICP组、妊娠高血压疾病组(P IH)、正常孕妇以及正常未孕女性及男性组血清总胆汁酸(TBA)的水平,同时对ICP组其他肝功能相关指标也进行检测。结果ICP组TBA水平较其他3组明显增高,而其他3组之间差异无显著性。ICP孕妇TBA与血清碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)、直接胆红素(DB IL)的检测水平有良好的相关性;且TBA在灵敏度和特异性上均优于以上指标。结论血清总胆汁酸的测定对孕妇胆汁淤积症的诊断、疗效评估以及预后判断均具有重要意义。
Objective To study the serum levels of total bile acid in normal and intrahepatic cholestasis pregnant women. Methods Serum levels of total bile acid were determined in patients with intrahepatic cholestasis of pregnancy, pregnancy-induced hypertension syndrome,normal pregnancy and no-pregnancy women and men. Adjusting other liver function related items were determined in patients with intrahepatic cholestasis of pregnancy. Result The serum levels of total bile acid in intrahepatic cholestasis of pregnancy were significantly higher than those in other groups, and there was no difference among other three groups. The TBA level were well-related to ALP,GGT ,DBIL in ICP group and TBA was better than the others in sensitivity and specificity. Conclusion Sersum total bile acid level is important in evaluating the diagnosis ,treatment and prognosis of intrahepatic cholestasis of pregnancy.
出处
《临床输血与检验》
CAS
2005年第4期250-251,共2页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
总胆汁酸
胆汁淤积症
Total bile acid
Intrahepatic cholestasis
