摘要
L-组氨酸(L-His)在醛的催化下,在羧酸溶剂中能发生消旋.当反应温度升高时,消旋反应速率加快.L-His用(R)-酒石酸((R)-TA)做拆分试剂,在乙酸溶剂中、水杨醛存在下进行不对称转换,合成了D-组氨酸(D-His)的酒石酸盐,经处理得到D-His.在最佳工艺条件下的收率为95.76%,光学纯度大于99.5%.
L- Histidine （L -His） could be racemized in carboxylic acids which were used as solvents in presence of catalyst such as butanal . The rate of racemization of L - His increased with the increase of the temperature. The water in carboxylic acid decreased the rate of racemization. An asymmetric transformation from L - His to D - His through formation of salt with （ R ） - tartaric acid was achieved by using salicylaldehyde as a catalyst for epimerization in acetic acid, and D - His （ R ） - TA salt was obtained, treatment of the salt gave D - His with optical purity 100 % in 95.76 % yield based on the starting material under the optimistic conditions.
出处
《东北师大学报（自然科学版）》
CAS
CSCD
北大核心
2005年第3期49-52,共4页
Journal of Northeast Normal University(Natural Science Edition)
基金
国家科技计划项目(2003EB020660)
关键词
L—His
D—His
消旋
不对称转换
L - histidine
D - histidine
racemization
asymmetric transformation
