摘要
目的研究盐酸林可霉素两种晶型晶体结构中不同分子构象及氢键对其中、近红外光谱行为的影响。方法单晶X-射线衍射法、红外吸收光谱法、近红外光谱法。结果盐酸林可霉素两种晶型分属不同晶系,它们在晶格中的分子构象与分子内、分子间氢键均不同,从而造成它们中、近红外光谱行为的显著差异。结论可用中、近红外光谱法鉴别盐酸林可霉素两种晶型并可实现工业结晶中的离线和原位监控。
Objective To study the influences of different molecular conformations and hydrogen bond in the different lincomycin hydrochloride crystal structures on their behaviour of middle infrared spectrum and near infrared spectrum. Methods X-ray diffraction of single crystal, middle infrared spectroscopy, near infrared spectroscopy were recorded. Results Crystal form I and crystal form Ⅱ belong to different crystal systems and space groups. Differences of two molecular conformations and hydrogen bonds of intra- and intermoleculars contribute to significant different behaviors of their IR spectroscopy. Conclusion Middle infrared spectroscopy and near infrared spectroscopy can be used to identify the crystal form I and crystal form Ⅱ of lincomycin hydrochloride and monitor the industrial crystallization process on/off -line.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2005年第9期529-532,共4页
Chinese Journal of Antibiotics
关键词
盐酸林可霉素
多晶型
分子构象
单晶X-射线衍射法
红外光谱法
近红外光谱法
Lincomycin hydrochloride
Polymorphism
Molecular conformation
X-ray diffraction of single crystal
Middle infra-red spectroscopy
Near infra-red spectroscopy.
